Pyrazoles are of considerable interest due to the broad variety of their biological activities.
This overview summarizes structures of pharmacologically interesting pyrazoles, natural …

The search of new antioxidants, as drugs candidates, is an active field of medicinal
chemistry. The synthesis of compounds with antioxidant potential has increased in recent …

Pyrazoles are an important class of heterocycles found in a wide range of bioactive
compounds and pharmaceuticals. Pyrazole synthesis often requires hydrazine or related …

We report two new efficient iron-catalyzed synthetic strategies for multicomponent synthesis
of tri-substituted pyrazoles using biomass-derived alcohols as the primary feedstock. A well …

A novel efficient tandem reaction of hydrazones and α-bromo ketones is reported for the
preparation of 1, 3, 5-trisubstituted pyrazoles by visible light catalysis. In this system, the …

An efficient synthesis of 1, 3, 5-trisubstituted pyrazoles from N-alkylated tosylhydrazones and
terminal alkynes was developed. The protocol was applied to a wide range of substrates …

Two efficient highly regioselective routes for the synthesis of unsymmetrically substituted 1-
aryl-3, 5-bis (het) arylpyrazoles with complementary regioselectivity starting from active …

Type 2 diabetes mellitus (DM) is a complex chronic disorder and a major global health
problem. Insulin resistance is the primary detectable abnormality and the main characteristic …

An efficient synthesis of pyrazoles from tosylhydrazones and nitroalkenes was developed. In
comparison with the previously reported 1, 3-dipolar cycloaddition reaction of diazo …

Pyrazole is the ubiquitous sub-structure of many natural products and biologically active
compounds. In this respect, its regioselective synthesis drew a lot of attention from synthetic …