Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Cancer drug resistance leading to therapeutic failure in the treatment of many cancers
encompasses various mechanisms and may be intrinsic relying on the patient's genetic …

DNA damage repair (DDR) pathways are essential to ensure the accurate transmission of
genetic material. However, different endogenous and exogenous factors challenge genomic …

Background New tools are needed to predict outcomes of ovarian cancer patients treated
with platinum-based chemotherapy. We hypothesized that a molecular score based on …

Merkel cell polyomavirus (MCPyV) is associated to Merkel cell carcinoma (MCC). We
studied 113 MCC tumoral skin lesions originating from 97 patients. MCPyV detection was …

Colorectal cancer (CRC) is one of the most common malignancies worldwide. Double-
strand break (DSB) is the most severe type of DNA damage. However, few reviews have …

Lead is still widely used in many industrial processes and is very persistent in the
environment. Although toxic effects caused by occupational exposure to lead have been …

Polymorphisms of LIG4 gene may influence DNA repair ability, thus altering the genetic
stability and resulting in carcinogenesis. A growing number of studies have investigated the …

The incidence of thyroid cancer, one of the most common forms of endocrine cancer, is
increasing rapidly worldwide in developed and developing countries. Various risk factors …

Chaga mushroom is one of the promising beneficial mushrooms thriving in the colder parts
of Northern hemisphere. Chaga polysaccharides (IOP) have been reported to enhance …