Biosensing with dnazymes

EM McConnell, I Cozma, Q Mou, JD Brennan… - Chemical Society …, 2021 - pubs.rsc.org
This article provides a comprehensive review of biosensing with DNAzymes, providing an
overview of different sensing applications while highlighting major progress and seminal …

Isothermal amplification of nucleic acids

Y Zhao, F Chen, Q Li, L Wang, C Fan - Chemical reviews, 2015 - ACS Publications
Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …

A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics

K Shi, S Xie, R Tian, S Wang, Q Lu, D Gao, C Lei… - Science …, 2021 - science.org
Artificial nucleic acid circuits with precisely controllable dynamic and function have shown
great promise in biosensing, but their utility in molecular diagnostics is still restrained by the …

Self-stacking autocatalytic molecular circuit with minimal catalytic DNA assembly

R Li, Y Zhu, X Gong, Y Zhang, C Hong… - Journal of the …, 2023 - ACS Publications
Isothermal autocatalytic DNA circuits have been proven to be versatile and powerful
biocomputing platforms by virtue of their self-sustainable and self-accelerating reaction …

A smart, autocatalytic, DNAzyme biocircuit for in vivo, amplified, microRNA imaging

J Wei, H Wang, Q Wu, X Gong, K Ma, X Liu… - Angewandte …, 2020 - Wiley Online Library
DNAzymes have been recognized as promising transducing agents for visualizing
endogenous biomarkers, but their inefficient intracellular delivery and limited amplification …

Construction of an Autocatalytic Hybridization Assembly Circuit for Amplified In Vivo MicroRNA Imaging

H Wang, Y He, J Wei, H Wang, K Ma… - Angewandte …, 2022 - Wiley Online Library
Lowly expressed analyte in complex cytoplasmic milieu necessitates the development of
non‐enzymatic autocatalytic DNA circuits with high amplification and anti‐interference …

[HTML][HTML] From cascaded catalytic nucleic acids to enzyme–DNA nanostructures: controlling reactivity, sensing, logic operations, and assembly of complex structures

F Wang, CH Lu, I Willner - Chemical reviews, 2014 - ACS Publications
DNA is one of the most fascinating biopolymers. Besides its central role as carrier of genetic
information and translation of the genetic code into proteins, DNA holds great promise as a …

Signal amplification in living cells: a review of microRNA detection and imaging

H Peng, AM Newbigging, MS Reid, JS Uppal… - Analytical …, 2019 - ACS Publications
MicroRNA (miRNA) is a class of endogenous, noncoding RNA with a typical length of 19−
23 nucleotides (nt). 1− 3 miRNA regulate the expression of specific genes by binding to …

A bimetallic metal–organic framework encapsulated with DNAzyme for intracellular drug synthesis and self‐sufficient gene therapy

Z Wang, J Niu, C Zhao, X Wang, J Ren… - Angewandte …, 2021 - Wiley Online Library
Although chemotherapy is one of the most widely used cancer treatments, there are serious
side effects, drug resistance, and secondary metastasis. To address these problems, herein …

Isothermal amplified detection of DNA and RNA

L Yan, J Zhou, Y Zheng, AS Gamson… - Molecular …, 2014 - pubs.rsc.org
This review highlights various methods that can be used for a sensitive detection of nucleic
acids without using thermal cycling procedures, as is done in PCR or LCR. Topics included …