The past, present and future of Dictyostelium as a model system
S Bozzaro - The International Journal of Developmental Biology, 2019 - iris.unito.it
The social amoeba Dictyostelium discoideum has been a preferred model organism during
the last 50 years, particularly for the study of cell motility and chemotaxis, phagocytosis and …
the last 50 years, particularly for the study of cell motility and chemotaxis, phagocytosis and …
[HTML][HTML] miR-150-5p suppresses tumor progression by targeting VEGFA in colorectal cancer
X Chen, X Xu, B Pan, K Zeng, M Xu, X Liu, B He… - Aging (albany …, 2018 - ncbi.nlm.nih.gov
Abstract MicroRNA-150-5p (miR-150-5p) has been implicated in tumor initiation and
progression in a variety of cancers. However, its roles in colorectal cancer (CRC) remain …
progression in a variety of cancers. However, its roles in colorectal cancer (CRC) remain …
Dictyostelium: An Important Source of Structural and Functional Diversity in Drug Discovery
Y Kubohara, H Kikuchi - Cells, 2018 - mdpi.com
The cellular slime mold Dictyostelium discoideum is an excellent model organism for the
study of cell and developmental biology because of its simple life cycle and ease of use …
study of cell and developmental biology because of its simple life cycle and ease of use …
DIF-1 inhibits growth and metastasis of triple-negative breast cancer through AMPK-mediated inhibition of the mTORC1-S6K signaling pathway
F Seto-Tetsuo, M Arioka, K Miura, T Inoue, K Igawa… - Oncogene, 2021 - nature.com
We have previously reported that the differentiation-inducing factor-1 (DIF-1), a compound
identified in Dictyostelium discoideum, suppresses the growth of MCF-7 breast cancer cells …
identified in Dictyostelium discoideum, suppresses the growth of MCF-7 breast cancer cells …
Differentiation-inducing factor-1 reduces lipopolysaccharide-induced vascular cell adhesion molecule-1 by suppressing mTORC1-S6K signaling in vascular …
M Arioka, F Seto-Tetsuo, T Inoue, K Miura, S Ishikane… - Life Sciences, 2023 - Elsevier
Abstract Aims Differentiation-inducing factor-1 (DIF-1), a compound in Dictyostelium
discoideum, exhibits anti-cancer effects by inhibiting cell proliferation and motility of various …
discoideum, exhibits anti-cancer effects by inhibiting cell proliferation and motility of various …
Celecoxib and 2, 5‐dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β‐catenin signaling pathway
I Egashira, F Takahashi‐Yanaga, R Nishida… - Cancer …, 2017 - Wiley Online Library
We previously reported that celecoxib, a selective COX‐2 inhibitor, strongly inhibited human
colon cancer cell proliferation by suppressing the Wnt/β‐catenin signaling pathway. 2, 5 …
colon cancer cell proliferation by suppressing the Wnt/β‐catenin signaling pathway. 2, 5 …
Anti-tumor effects of differentiation-inducing factor-1 in malignant melanoma: GSK-3-mediated inhibition of cell proliferation and GSK-3-independent suppression of …
M Arioka, F Takahashi-Yanaga, M Kubo… - Biochemical …, 2017 - Elsevier
Abstract Differentiation-inducing factor-1 (DIF-1) isolated from Dictyostelium discoideum
strongly inhibits the proliferation of various mammalian cells through the activation of …
strongly inhibits the proliferation of various mammalian cells through the activation of …
DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer …
F Seto-Tetsuo, M Arioka, K Miura, T Inoue… - International …, 2023 - Elsevier
The tumor microenvironment (TME), largely composed of tumor-associated macrophages
(TAMs) and cancer-associated fibroblasts (CAFs), plays a key role in cancer progression. A …
(TAMs) and cancer-associated fibroblasts (CAFs), plays a key role in cancer progression. A …
Mammalian target of differentiation-inducing factor-1 is mitochondrial malate dehydrogenase for activation of AMP-activated protein kinase and induction of …
M Arioka, K Miura, R Han, K Igawa… - Life Sciences, 2024 - Elsevier
Abstract Aims Differentiation-inducing factor-1 (DIF-1) is a polyketide produced by
Dictyostelium discoideum that inhibits growth and migration, while promoting the …
Dictyostelium discoideum that inhibits growth and migration, while promoting the …
[HTML][HTML] MiR-422a targets MAPKK6 and regulates cell growth and apoptosis in colorectal cancer cells
P Li, Q Li, Y Zhang, S Sun, S Liu, Z Lu - Biomedicine & Pharmacotherapy, 2018 - Elsevier
The important role of miR-422a in tumor has been reported in several studies. Recent
research discovered that the expression of miR-422a was significantly decreased in …
research discovered that the expression of miR-422a was significantly decreased in …