Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) brutally perils physical and
mental health worldwide. Unavailability of effective anti-viral drug rendering global threat of …
mental health worldwide. Unavailability of effective anti-viral drug rendering global threat of …
[HTML][HTML] An overview of potential inhibitors targeting non-structural proteins 3 (PLpro and Mac1) and 5 (3CLpro/Mpro) of SARS-CoV-2
F Yan, F Gao - Computational and structural biotechnology journal, 2021 - Elsevier
There is an urgent need to develop effective treatments for coronavirus disease 2019
(COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS …
(COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS …
Taguchi design-assisted co-immobilization of lipase A and B from Candida antarctica onto chitosan: Characterization, kinetic resolution application, and docking …
KS Moreira, ALB de Oliveira… - … Research and Design, 2022 - Elsevier
In the present communication, the simultaneous co-immobilization by covalent binding of
lipase A from Candida antarctica (CALA) and lipase B from Candida antarctica (CALB) in …
lipase A from Candida antarctica (CALA) and lipase B from Candida antarctica (CALB) in …
Identification of alkaloids from Justicia adhatoda as potent SARS CoV-2 main protease inhibitors: An in silico perspective
R Ghosh, A Chakraborty, A Biswas… - Journal of molecular …, 2021 - Elsevier
The COVID-19 pandemic, caused by SARS CoV-2, is responsible for millions of death
worldwide. No approved/proper therapeutics is currently available which can effectively …
worldwide. No approved/proper therapeutics is currently available which can effectively …
Plant-based phytochemical screening by targeting main protease of SARS-CoV-2 to design effective potent inhibitors
Simple Summary Virtual screening schemes, including molecular docking in conjunction
with molecular dynamics simulation, were accomplished, as they extend an ample …
with molecular dynamics simulation, were accomplished, as they extend an ample …
Virtual screening, ADMET prediction and dynamics simulation of potential compounds targeting the main protease of SARS-CoV-2
The coronavirus disease-2019 caused by a novel SARS CoV-2 virus has emerged as a
global threat. Still, no drugs are available for its treatment. The main protease is the most …
global threat. Still, no drugs are available for its treatment. The main protease is the most …
[HTML][HTML] An understanding of coronavirus and exploring the molecular dynamics simulations to find promising candidates against the Mpro of nCoV to combat the …
The first infection case of new coronavirus was reported at the end of 2019 and after then,
the cases are reported in all nations across the world in a very short period. Further, the …
the cases are reported in all nations across the world in a very short period. Further, the …
Discovery of nirmatrelvir resistance mutations in SARS-CoV-2 3CLpro: A computational-experimental approach
B Havranek, R Demissie, H Lee, S Lan… - Journal of chemical …, 2023 - ACS Publications
The COVID-19 pandemic has emphasized the urgency for effective antiviral therapies
against SARS-CoV-2. Targeting the main protease (3CLpro) of the virus has emerged as a …
against SARS-CoV-2. Targeting the main protease (3CLpro) of the virus has emerged as a …
Molecular docking as a potential approach in repurposing drugs against COVID-19: A systematic review and novel pharmacophore models
M Fadlalla, M Ahmed, M Ali, AA Elshiekh… - Current Pharmacology …, 2022 - Springer
Abstract Purpose of Review This article provides a review of the recent literature related to
the FDA-approved drugs that had been repurposed as potential drug candidates against …
the FDA-approved drugs that had been repurposed as potential drug candidates against …
Biflavonoids from Rhus succedanea as probable natural inhibitors against SARS-CoV-2: a molecular docking and molecular dynamics approach
K Lokhande, N Nawani… - Journal of …, 2022 - Taylor & Francis
The recent outbreak of SARS-CoV-2 has quickly become a worldwide pandemic and
generated panic threats for both the human population and the global economy. The …
generated panic threats for both the human population and the global economy. The …