Progress and perspective on hydrogen sulfide donors and their biomedical applications

ZL Song, L Zhao, T Ma, A Osama… - Medicinal Research …, 2022 - Wiley Online Library
Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide
(H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have …

Reaction-based luminescent probes for reactive sulfur, oxygen, and nitrogen species: analytical techniques and recent progress

BJ Bezner, LS Ryan, AR Lippert - Analytical Chemistry, 2019 - ACS Publications
Gasotransmitters and related reactive sulfur, oxygen, and nitrogen species such as nitric
oxide (NO), hydrogen sulfide (H2S), carbon monoxide (CO), hydrogen peroxide (H2O2), and …

Development and Application of Carbonyl Sulfide-Based Donors for H2S Delivery

CM Levinn, MM Cerda, MD Pluth - Accounts of chemical research, 2019 - ACS Publications
Conspectus In addition to nitric oxide and carbon monoxide, hydrogen sulfide (H2S) has
been recently recognized as an important biological signaling molecule with implications in …

Activatable small-molecule hydrogen sulfide donors

CM Levinn, MM Cerda, MD Pluth - Antioxidants & redox signaling, 2020 - liebertpub.com
Significance: Hydrogen sulfide (H2S) is an important biological signaling molecule involved
in many physiological processes. These diverse roles have led researchers to develop …

Photoactivated hydrogen sulfide donor with a near-infrared fluorescence report system for accelerated chronic wound healing

F Yuan, X He, Y Lu, L Ning, X Zhao, S Zhang… - Analytical …, 2023 - ACS Publications
Delayed wound healing is one of the major diabetes complications that occur in 25% of
diabetic patients. Specific wound management and combination treatment are required to …

Subcellular delivery of hydrogen sulfide using small molecule donors impacts organelle stress

AK Gilbert, MD Pluth - Journal of the American Chemical Society, 2022 - ACS Publications
Hydrogen sulfide (H2S) is an endogenously produced gaseous signaling molecule with
important roles in regulating organelle function and stress. Because of its high reactivity …

Physiological functions and donor design of hydrogen sulfide and its application in central nervous system diseases

Z Zhao, W Guo, C Xu, Q Wang, C Mao… - Chemical Engineering …, 2023 - Elsevier
In the past decades, hydrogen sulfide (H 2 S) has been considered as an important signal
molecule with a wide range of physiological functions. Therefore, disease treatment …

Development of Acid-Mediated H2S/COS Donors That Respond to a Specific pH Window

AK Gilbert, Y Zhao, CE Otteson… - The Journal of organic …, 2019 - ACS Publications
Hydrogen sulfide (H2S) is a biologically relevant molecule, and recent efforts have focused
on developing small molecular donors that deliver H2S on demand. Acid-activated donors …

Chemiluminescence detection of hydrogen sulfide release by β-lactamase-catalyzed β-lactam biodegradation: Unprecedented pathway for monitoring β-lactam …

SP Gholap, C Yao, O Green, M Babjak… - Bioconjugate …, 2021 - ACS Publications
β-Lactamase positive bacteria represent a growing threat to human health because of their
resistance to commonly used antibiotics. Therefore, development of new diagnostic methods …

Esterase-Responsive Fluorogenic Prodrugs of Aldose Reductase Inhibitor Epalrestat: An Innovative Strategy toward Enhanced Anticancer Activity

R Misra, P Barman, KP Bhabak - ACS Applied Bio Materials, 2024 - ACS Publications
In addition to the conventional chemotherapeutic drugs, potent inhibitors of key enzymes
that are differentially overexpressed in cancer cells and associated with its progression are …