The role of epicardial adipose tissue dysfunction in cardiovascular diseases: An overview of pathophysiology, evaluation, and management

C Li, X Liu, BK Adhikari, L Chen, W Liu… - Frontiers in …, 2023 - frontiersin.org
In recent decades, the epicardial adipose tissue (EAT) has been at the forefront of scientific
research because of its diverse role in the pathogenesis of cardiovascular diseases (CVDs) …

The effects of Sodium-glucose cotransporter 2 inhibitors on adipose tissue in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

X Liu, Y Chen, T Liu, L Cai, X Yang… - Frontiers in Endocrinology, 2023 - frontiersin.org
Purpose To systematically evaluate the effect of Sodium-glucose cotransporter 2 (SGLT2)
inhibitors on adipose tissue in patients with type 2 diabetes. Methods We searched PubMed …

Dapagliflozin treatment is associated with a reduction of epicardial adipose tissue thickness and epicardial glucose uptake in human type 2 diabetes

F Cinti, L Leccisotti, GP Sorice, U Capece… - Cardiovascular …, 2023 - Springer
Objective We recently demonstrated that treatment with sodium-glucose cotransporter-2
inhibitors (SGLT-2i) leads to an increase in myocardial flow reserve in patients with type 2 …

Haemodynamic and metabolic phenotyping of patients with aortic stenosis and preserved ejection fraction: a specific phenotype of heart failure with preserved …

N De Biase, M Mazzola, L Del Punta… - European Journal of …, 2023 - Wiley Online Library
Aims Degenerative aortic valve stenosis with preserved ejection fraction (ASpEF) and heart
failure with preserved ejection fraction (HFpEF) display intriguing similarities. This study …

Characterizing diabetic cardiomyopathy: baseline results from the ARISE-HF trial

JL Januzzi, S Del Prato, J Rosenstock, J Butler… - Cardiovascular …, 2024 - Springer
Abstract Background Diabetic cardiomyopathy (DbCM) is a form of Stage B heart failure (HF)
at high risk for progression to overt disease. Using baseline characteristics of study …

Pioglitazone reduces epicardial fat and improves diastolic function in patients with type 2 diabetes

AJ Moody, M Molina‐Wilkins, GD Clarke… - Diabetes, Obesity …, 2023 - Wiley Online Library
Aims To examine the effect of pioglitazone on epicardial (EAT) and paracardial adipose
tissue (PAT) and measures of diastolic function and insulin sensitivity in patients with type 2 …

Association between epicardial adipose tissue and cardiac dysfunction in subjects with severe obesity

JF Chin, YS Aga, S Abou Kamar… - European Journal of …, 2023 - Wiley Online Library
Aim Epicardial adipose tissue (EAT) plays a role in obesity‐related heart failure with
preserved ejection fraction. However, the association of EAT thickness with the development …

Epicardial fat in heart failure—Friend, foe, or bystander

A Paterek, M Załęska‐Kocięcka, Z Wojdyńska… - Obesity …, 2024 - Wiley Online Library
Epicardial adipose tissue (EAT) is a fat depot covering the heart. No physical barrier
separates EAT from the myocardium, so EAT can easily affect the underlying cardiac …

Distinct effects of type 2 diabetes and obesity on cardiopulmonary performance

L Nesti, NR Pugliese, L Santoni… - Diabetes, Obesity …, 2024 - Wiley Online Library
Aim Effort intolerance is frequent in patients with overweight/obesity and/or type 2 diabetes
(T2D) free from cardiac and respiratory disease. We sought to quantify the independent …

Obesity: The perfect storm for heart failure

M Lembo, T Strisciuglio, C Fonderico… - ESC Heart …, 2024 - Wiley Online Library
Obesity condition causes morphological and functional alterations involving the
cardiovascular system. These can represent the substrates for different cardiovascular …