Chemogenetics is an approach for engineering proteins to enable their modulation by
otherwise inert small molecules. Although kinases, enzymes and ion channels have been …

Executive control, the ability to organize thoughts and action plans in real time, is a defining
feature of higher cognition. Classical theories have emphasized cortical contributions to this …

Epilepsy is a disorder in which abnormal neuronal hyperexcitation causes several types of
seizures. Because pharmacological and surgical treatments occasionally interfere with …

Visual object memory is a fundamental element of various cognitive abilities, and the
underlying neural mechanisms have been extensively examined especially in the anterior …

Due to its low invasiveness and controllability, chemogenetic approaches offer a highly
attractive option to modulate neuronal activity in basic research and future clinical …

The chemogenetic technology referred to as designer receptors exclusively activated by
designer drugs (DREADDs) offers reversible means to control neuronal activity for …

Dysfunction in dopamine (DA) signaling contributes to neurological disorders ranging from
drug addiction and schizophrenia to depression and Parkinson's Disease. How might …

Concurrent genetic neuromodulation and functional magnetic resonance imaging (fMRI) in
primates has provided a valuable opportunity to assess the modified brain-wide operation in …

Evidence suggests that subcortical structures play a role in high-level cognitive functions
such as the allocation of spatial attention. While there is abundant evidence in humans for …

Primates must adapt to changing environments by optimizing their behavior to make
beneficial choices. At the core of adaptive behavior is the orbitofrontal cortex (OFC) of the …