Histone modifications (HMs) contribute to maintaining genomic stability, transcription, DNA
repair, and modulating chromatin in cancer cells. Furthermore, HMs are dynamic and …

Background Established measurements of proliferation in breast cancer are Ki67 and mitotic-
activity-index (MAI), with problems in reproducibility and prognostic accuracy …

Aims During pathological examination of breast tumours, proliferative activity is routinely
evaluated by a count of mitoses. Adding immunohistochemical stains of Ki67 provides extra …

We investigated possible clinical and histopathological prognostic factors in a malignant
meningioma cohort with comprehensive long-term population-based follow-up data. Twenty …

The main aim of the present study was to investigate the biological function of uric acid. The
level of uric acid in different organs in normal male rats was determined with uric acid assay …

Despite recent evidence for an anti-tumour role for high-dose ascorbate, potential
mechanisms of action are still unclear. At mM concentrations that are achieved with high …

Background Mitotic count in breast cancer is an important prognostic marker. Unfortunately,
substantial inter‐and intraobserver variation exists when pathologists manually count mitotic …

The mechanisms by which breast cancers progress from relatively indolent ductal carcinoma
in situ (DCIS) to invasive ductal carcinoma (IDC) are not well understood. However, this …

Gozhenko AI, Korda MM, Smagliy VS, Badiuk NS, Zukow W, Klishch MI, Korda IV,
Bombushkar IS, Popovych IL. Uric Acid, Metabolism, Neuro-Endocrine-Immine Complex …

Background and Objectives Emerging evidence suggests that the presence of atypical
mitoses is associated with poor prognosis in some types of cancer, but its clinical …