Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Transient receptor potential (TRP) ion channels are emerging as a new set of membrane
proteins involved in a vast array of cellular processes and regulated by a large number of …

Spinal muscular atrophies (SMA, also known as hereditary motor neuropathies) and
hereditary motor and sensory neuropathies (HMSN) are clinically and genetically …

ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential
(TRP) channels that are activated by changes in the environmental temperature, from …

Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having
varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being …

Ion channels activate by sensing stimuli such as membrane voltage, ligand binding or
temperature and transduce this information into conformational changes that open the …

Although a unifying characteristic common to all transient receptor potential (TRP) channel
functions remains elusive, they could be described as tetramers formed by subunits with six …

Six highly temperature-sensitive ion channels of the transient receptor potential (TRP) family
have been implicated to mediate temperature sensation. These channels, expressed in …

The classic heat shock (stress) response (HSR) was originally attributed to protein
denaturation. However, heat shock protein (Hsp) induction occurs in many circumstances …

Opioids, agonists of µ-opioid receptors (µORs), are the strongest pain killers clinically
available. Their action includes a strong central component, which also causes important …