Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

Fc‐Fusion proteins represent a successful class of biopharmaceutical products, with already
13 drugs approved in the European Union and United States as well as three biosimilar …

Alterations in protein structure may have profound effects on biological function. Analytical
techniques that permit characterization of proteins while maintaining their conformational …

Ion-exchange chromatography (IEC) is a chromatographic technique commonly used for the
separation of ions and ionizable molecules. Its direct coupling with mass spectrometry has …

Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …

Accelerated development of new therapeutics in an increasingly competitive landscape
requires the use of high throughput analytical platforms. In addition, the complexity of novel …

N-glycosylation of therapeutic antibodies starts as a co-translational step followed by a set of
post-translational modifications and is considered as one of the critical quality attributes …

Complete self-assembly and reassembly behavior of bitter peptide-protein necessitates
multilevel theories that encompass phenomena ranging from the self-assembly of …

Antibody–drug conjugates (ADCs) are biopharmaceuticals produced by chemically linking
small molecules (payloads) to antibodies that possess specific affinity for the target cell. The …

This work describes the direct hyphenation of cation exchange chromatography (CEX) with
a compact, easy-to-use benchtop Time of Flight mass spectrometer (ToF/MS) for the …