The retinoblastoma protein RB and the transcription factor p53 are central tumor
suppressors. They are often found inactivated in various tumor types. Both proteins play …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB): E2F
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …

Ki-67 serves as a prominent cancer marker. We describe how expression of the MKI67 gene
coding for Ki-67 is controlled during the cell cycle. MKI67 mRNA and Ki-67 protein are …

The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has
remained unknown whether not only lesion-type-specific, but overall repair capacities could …

The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive
cell proliferation. A well-known target of cyclin D-Cdk4, 6 is the retinoblastoma protein Rb …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

Most human cancers acquire mutations causing defects in the p53 signaling pathway. The
tumor suppressor p53 becomes activated in response to genotoxic stress and is essential for …

Perfectly orchestrated periodic gene expression during cell cycle progression is essential for
maintaining genome integrity and ensuring that cell proliferation can be stopped by …