The microbiome in the gut is a diverse environment, housing the majority of our bacterial
microbes. This microecosystem has a symbiotic relationship with the surrounding …

Functional recovery from peripheral nerve injury and repair depends on a multitude of
factors, both intrinsic and extrinsic to neurons. Neuronal survival after axotomy is a …

Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …

DURING the initial phase of their development, sensory neurons of the dorsal root ganglion
(DRG) require target-derived trophic support for their survival1–3, but as they mature they …

For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …

Nerve growth factor (NGF) has long occupied a central position in developmental
neurobiology because of the many important neuronal functions it has been shown to …

Brain-derived neurotrophic factor (BDNF), a neurotrophin, enhances the survival and
differentiation of several classes of neurons in vitro. To determine fts esaential functions, we …

Neurotrophic factors are essential contributors to the survival of peripheral and central
nervous system (CNS) neurons, and demonstration of their reduced availability in diseased …

The neurotrophin family includes NGF, brain-derived neurotrophic factor (BDNF),
neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Previous studies have demonstrated that …

Abstract Neurotrophin-3-deficient (NT-3-deficient) mice were generated by gene targeting.
Mutant mice displayed severe movement defects of the limbs, and most died shortly after …