White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies

P Ballabh, LS de Vries - Nature Reviews Neurology, 2021 - nature.com
Intraventricular haemorrhage (IVH) continues to be a major complication of prematurity that
can result in cerebral palsy and cognitive impairment in survivors. No optimal therapy exists …

Germinal matrix-intraventricular hemorrhage of the preterm newborn and preclinical models: inflammatory considerations

I Atienza-Navarro, P Alves-Martinez… - International journal of …, 2020 - mdpi.com
The germinal matrix-intraventricular hemorrhage (GM-IVH) is one of the most important
complications of the preterm newborn. Since these children are born at a critical time in …

Free radicals and neonatal brain injury: from underlying pathophysiology to antioxidant treatment perspectives

S Martini, L Castellini, R Parladori, V Paoletti, A Aceti… - Antioxidants, 2021 - mdpi.com
Free radicals play a role of paramount importance in the development of neonatal brain
injury. Depending on the pathophysiological mechanisms underlying free radical …

The role of oxidative stress in the progression of secondary brain injury following germinal matrix hemorrhage

M Nour Eldine, M Alhousseini, W Nour-Eldine… - Translational Stroke …, 2024 - Springer
Germinal matrix hemorrhage (GMH) can be a fatal condition responsible for the death of
1.7% of all neonates in the USA. The majority of GMH survivors develop long-term sequalae …

Microglia-derived CCL20 deteriorates neurogenesis following intraventricular hemorrhage

N Yao, Y Li, J Han, S Wu, X Liu, Q Wang, Z Li… - Experimental …, 2023 - Elsevier
Intraventricular hemorrhage (IVH) commonly occurs as an extension of intracerebral
hemorrhage (ICH) into the brain ventricular system, leading to worse outcomes without …

Temporal brain transcriptome analysis reveals key pathological events after germinal matrix hemorrhage in neonatal rats

J Song, G Nilsson, Y Xu, A Zelco… - Journal of Cerebral …, 2022 - journals.sagepub.com
Germinal matrix hemorrhage (GMH) is a common complication in preterm infants and is
associated with high risk of adverse neurodevelopmental outcomes. We used a rat GMH …

Antenatal and postnatal sequelae of oxidative stress in preterm infants: a narrative review targeting pathophysiological mechanisms

S Martini, A Aceti, AN Della Gatta, I Beghetti, C Marsico… - Antioxidants, 2023 - mdpi.com
The detrimental effects of oxidative stress (OS) can start as early as after conception. A
growing body of evidence has shown the pivotal role of OS in the development of several …

[HTML][HTML] Innate immune activation and white matter injury in a rat model of neonatal intraventricular hemorrhage are dependent on developmental stage

M Zamorano, SD Olson, C Haase, JJ Herrera… - Experimental …, 2023 - Elsevier
Background Inflammation and white matter injury are consequences of neonatal
intraventricular hemorrhage (IVH). Both white matter and the neuroimmune system are …

Hemoglobin induces oxidative stress and mitochondrial dysfunction in oligodendrocyte progenitor cells

CD Pandya, H Vekaria, B Joseph, SA Slone… - Translational …, 2021 - Elsevier
Oligodendrocyte progenitor cells (OPCs) in the infant brain give rise to mature
oligodendrocytes that myelinate CNS axons. OPCs are particularly vulnerable to oxidative …

Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review

KG Holste, F Xia, F Ye, RF Keep, G Xi - Fluids and Barriers of the CNS, 2022 - Springer
Intraventricular hemorrhage (IVH) is a significant cause of morbidity and mortality in both
neonatal and adult populations. IVH not only causes immediate damage to surrounding …