Epstein Barr virus: development of vaccines and immune cell therapy for EBV-associated diseases

X Cui, CM Snapper - Frontiers in Immunology, 2021 - frontiersin.org
Epstein-Barr virus (EBV) is the first human tumor virus discovered and is strongly implicated
in the etiology of multiple lymphoid and epithelial cancers. Each year EBV associated …

Current perspectives in cancer immunotherapy

T Christofi, S Baritaki, L Falzone, M Libra, A Zaravinos - Cancers, 2019 - mdpi.com
Different immunotherapeutic approaches have proved to be of significant clinical value to
many patients with different types of advanced cancer. However, we need more precise …

The role of Epstein–Barr virus in nasopharyngeal carcinoma

ZY Su, PY Siak, CO Leong, SC Cheah - Frontiers in Microbiology, 2023 - frontiersin.org
Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy closely associated
with the Epstein–Barr virus (EBV). Despite ubiquitous infection of EBV worldwide, NPC …

EBV-associated diseases: Current therapeutics and emerging technologies

S Chakravorty, B Afzali, M Kazemian - Frontiers in Immunology, 2022 - frontiersin.org
EBV is a prevalent virus, infecting> 90% of the world's population. This is an oncogenic virus
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …

MET-induced CD73 restrains STING-mediated immunogenicity of EGFR-mutant lung cancer

R Yoshida, M Saigi, T Tani, BF Springer, H Shibata… - Cancer research, 2022 - AACR
Immunotherapy has shown limited efficacy in patients with EGFR-mutated lung cancer.
Efforts to enhance the immunogenicity of EGFR-mutated lung cancer have been …

[HTML][HTML] CAR T cells targeting tumor endothelial marker CLEC14A inhibit tumor growth

X Zhuang, F Maione, J Robinson, M Bentley, B Kaul… - JCI insight, 2020 - ncbi.nlm.nih.gov
Engineering T cells to express chimeric antigen receptors (CARs) specific for antigens on
hematological cancers has yielded remarkable clinical responses, but with solid tumors …

Strategies to genetically engineer T cells for cancer immunotherapy

TT Spear, K Nagato, MI Nishimura - Cancer Immunology, Immunotherapy, 2016 - Springer
Immunotherapy is one of the most promising and innovative approaches to treat cancer, viral
infections, and other immune-modulated diseases. Adoptive immunotherapy using gene …

Redirecting T cells against epstein–barr virus infection and associated oncogenesis

C Münz - Cells, 2020 - mdpi.com
The Epstein–Barr virus (EBV) is associated with lymphomas and carcinomas. For some of
these, the adoptive transfer of EBV specific T cells has been therapeutically explored, with …

A novel Epstein–Barr virus-latent membrane protein-1-specific T-cell receptor for TCR gene therapy

HI Cho, UH Kim, AR Shin, JN Won, HJ Lee… - British journal of …, 2018 - nature.com
Background: Adoptive transfer of genetically engineered T-cells to express antigen-specific
T-cell receptor (TCR) is a feasible and effective therapeutic approach for numerous types of …

EBV-induced T-cell responses in EBV-specific and nonspecific cancers

Q Zhang, M Xu - Frontiers in Immunology, 2023 - frontiersin.org
Epstein-Barr virus (EBV) is a ubiquitous human tumor virus associated with various
malignancies, including B-lymphoma, NK and T-lymphoma, and epithelial carcinoma. It …