Vanadium in biological action: chemical, pharmacological aspects, and metabolic implications in diabetes mellitus

S Treviño, A Díaz, E Sánchez-Lara… - Biological trace element …, 2019 - Springer
Vanadium compounds have been primarily investigated as potential therapeutic agents for
the treatment of various major health issues, including cancer, atherosclerosis, and …

Vanadium: Risks and possible benefits in the light of a comprehensive overview of its pharmacotoxicological mechanisms and multi-applications with a summary of …

A Ścibior, Ł Pietrzyk, Z Plewa, A Skiba - … of Trace Elements in Medicine and …, 2020 - Elsevier
Background Vanadium (V) is an element with a wide range of effects on the mammalian
organism. The ability of this metal to form organometallic compounds has contributed to the …

Binding of vanadium ions and complexes to proteins and enzymes in aqueous solution

JC Pessoa, MFA Santos, I Correia, D Sanna… - Coordination Chemistry …, 2021 - Elsevier
The understanding of the role of vanadium enzymes and of vanadium compounds (VCs) in
biology, as well as the design of new vanadium-based species for catalysis, materials …

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications

E Del Carpio, L Hernández, C Ciangherotti… - Coordination chemistry …, 2018 - Elsevier
In the last 30 years, since the discovery that vanadium is a cofactor found in certain enzymes
of tunicates and possibly in mammals, different vanadium-based drugs have been …

Copper complexes with 1, 10-phenanthroline derivatives: Underlying factors affecting their cytotoxicity

P Nunes, I Correia, F Marques, AP Matos… - Inorganic …, 2020 - ACS Publications
The interpretation of in vitro cytotoxicity data of Cu (II)-1, 10-phenanthroline (phen)
complexes normally does not take into account the speciation that complexes undergo in …

Therapeutic potential of vanadium complexes with 1, 10-phenanthroline ligands, quo vadis? Fate of complexes in cell media and cancer cells

P Nunes, I Correia, I Cavaco, F Marques… - Journal of Inorganic …, 2021 - Elsevier
Abstract V IV O-complexes formulated as [V IV O (OSO 3)(phen) 2](1)(phen= 1, 10-
phenanthroline),[V IV O (OSO 3)(Me 2 phen) 2](2)(Me 2 phen= 4, 7-dimethyl-1, 10 …

A Short‐Lived but Highly Cytotoxic Vanadium (V) Complex as a Potential Drug Lead for Brain Cancer Treatment by Intratumoral Injections

A Levina, A Pires Vieira, A Wijetunga… - Angewandte Chemie …, 2020 - Wiley Online Library
The chemistry and short lifetimes of metal‐based anti‐cancer drugs can be turned into an
advantage for direct injections into tumors, which then allow the use of highly cytotoxic …

Misinterpretations in evaluating interactions of vanadium complexes with proteins and other biological targets

JC Pessoa, I Correia - Inorganics, 2021 - mdpi.com
In aqueous media, VIV-and VV-ions and compounds undergo chemical changes such as
hydrolysis, ligand exchange and redox reactions that depend on pH and concentration of …

Hydrophobicity may enhance membrane affinity and anti-cancer effects of Schiff base vanadium (v) catecholate complexes

DC Crans, JT Koehn, SM Petry, CM Glover… - Dalton …, 2019 - pubs.rsc.org
Anti-cancer activities of vanadium compounds have generated recent interest because of a
combination of desirable properties for chemotherapy, ie, strong cytotoxicities, anti …

Implications of Protein Interaction in the Speciation of Potential VIVO–Pyridinone Drugs

G Ferraro, M Paolillo, G Sciortino, F Pisanu… - Inorganic …, 2023 - ACS Publications
Vanadium complexes (VCs) are promising agents for the treatment, among others, of
diabetes and cancer. The development of vanadium-based drugs is mainly limited by a …