The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …

Simple Summary Cancer-associated fibroblasts (CAFs) are found in the tumor
microenvironment and exhibit several protumorigenic functions. Preclinical studies suggest …

Abstract N 6-methyladenosine (m6A), the most abundant internal messenger RNA
modification in higher eukaryotes, serves myriad roles in regulating cellular processes …

Prostate cancer adeno-to-neuroendocrine lineage transition has emerged as a mechanism
of targeted therapeutic resistance. Identifying the direct molecular drivers and developing …

Understanding the molecular programs that guide differentiation during development is a
major challenge. Here, we introduce Waddington-OT, an approach for studying …

Transcription factors (TFs) recognize specific DNA sequences to control chromatin and
transcription, forming a complex system that guides expression of the genome. Despite keen …

Recent evidence has elucidated how multipotent blood progenitors transform their identities
in the thymus and undergo commitment to become T cells. Together with environmental …

Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago,
enormous progress has been made in stem cell biology and regenerative medicine. Human …

Following fertilization, the two specified gametes must unite to create an entirely new
organism. The genome is initially transcriptionally quiescent, allowing the zygote to be …

Some cancers evade targeted therapies through a mechanism known as lineage plasticity,
whereby tumor cells acquire phenotypic characteristics of a cell lineage whose survival no …