High-level folding of chromatin is a key determinant of the shape and functional state of
chromosomes. During cell division, structural maintenance of chromosome (SMC) …

Cohesin connects CTCF-binding sites and other genomic loci in cis to form chromatin loops
and replicated DNA molecules in trans to mediate sister chromatid cohesion. Whether …

Structural maintenance of chromosome (SMC) proteins play a key roles in the chromosome
organization by condensing two meters of DNA into cell-sized structures considered as the …

The most prominent representatives of multisubunit SMC complexes, cohesin and
condensin, are best known as structural components of mitotic chromosomes. It turned out …

Most animal genomes are partitioned into Topologically Associating Domains (TADs),
created by cohesin-mediated loop extrusion and defined by convergently oriented CTCF …

DNA loop extrusion is arguably one of the most important players in genome organization.
The precise mechanism by which loop extruding factors (LEFs) work is still unresolved and …

The R-loop is a common transcriptional by-product that consists of an RNA-DNA duplex
joined to a displaced strand of genomic DNA. While the effects of R-loops on health and …

In this paper, the multi-beam line measurement problem is studied, solving the relevant data
of different seabed slope and line measurement, and establishing a multi-beam line …