Bax/Bcl-2 cascade is regulated by the EGFR pathway: therapeutic targeting of non-small cell lung cancer
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …
is involved in several cancer developments, including NSCLC. The EGFR pathway …
The key role of sphingolipid metabolism in cancer: New therapeutic targets, diagnostic and prognostic values, and anti-tumor immunotherapy resistance
RZ Li, XR Wang, J Wang, C Xie, XX Wang… - Frontiers in …, 2022 - frontiersin.org
Biologically active sphingolipids are closely related to the growth, differentiation, aging, and
apoptosis of cancer cells. Some sphingolipids, such as ceramides, are favorable metabolites …
apoptosis of cancer cells. Some sphingolipids, such as ceramides, are favorable metabolites …
Mast cell–tumor interactions: molecular mechanisms of recruitment, intratumoral communication and potential therapeutic targets for tumor growth
D Segura-Villalobos, IG Ramírez-Moreno… - Cells, 2022 - mdpi.com
Mast cells (MCs) are tissue-resident immune cells that are important players in diseases
associated with chronic inflammation such as cancer. Since MCs can infiltrate solid tumors …
associated with chronic inflammation such as cancer. Since MCs can infiltrate solid tumors …
Therapeutic implications and clinical manifestations of thymoquinone
Thymoquinone (TQ), a natural phytochemical predominantly found in Nigella sativa, has
been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and …
been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and …
Structure-guided design and development of cyclin-dependent kinase 4/6 inhibitors: a review on therapeutic implications
Abstract Cyclin-dependent kinase 6 (EC 2.7. 11.22) play significant roles in numerous
biological processes and triggers cell cycle events. CDK6 controlled the transcriptional …
biological processes and triggers cell cycle events. CDK6 controlled the transcriptional …
The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target
Cancer chemoresistance is a problematic dilemma that significantly restrains numerous
cancer management protocols. It can promote cancer recurrence, spreading of cancer, and …
cancer management protocols. It can promote cancer recurrence, spreading of cancer, and …
Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy
The human genome encodes more than 500 protein kinases that work by transferring the γ-
phosphate group from ATP to serine, threonine, or tyrosine (Ser/Thr/Tyr) residues. Various …
phosphate group from ATP to serine, threonine, or tyrosine (Ser/Thr/Tyr) residues. Various …
A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
ND Bergkamp, JR van Senten, HJ Brink… - Science …, 2023 - science.org
The G protein–coupled receptor (GPCR) US28 encoded by the human cytomegalovirus
(HCMV) is associated with accelerated progression of glioblastomas, aggressive brain …
(HCMV) is associated with accelerated progression of glioblastomas, aggressive brain …
Investigating potential of cholic acid, syringic acid, and mangiferin as cancer therapeutics through sphingosine kinase 1 inhibition
The signaling of sphingosine kinase 1 (SphK1) and sphingosine-1-phosphate (S1P)
regulates various diseases, including multiple sclerosis, atherosclerosis, rheumatoid …
regulates various diseases, including multiple sclerosis, atherosclerosis, rheumatoid …
[HTML][HTML] A Theranostic Small-Molecule Prodrug Conjugate for Neuroendocrine Prostate Cancer
After androgen deprivation therapy, a significant number of prostate cancer cases progress
with a therapy-resistant neuroendocrine phenotype (NEPC). This represents a challenge for …
with a therapy-resistant neuroendocrine phenotype (NEPC). This represents a challenge for …