Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature
Despite massive investments in drug research and development, the significant decline in
the number of new drugs approved or translated to clinical use raises the question, whether …
the number of new drugs approved or translated to clinical use raises the question, whether …
[HTML][HTML] Efficacy and mechanism of action of the tyrosine kinase inhibitors gefitinib, lapatinib and neratinib in the treatment of HER2-positive breast cancer: preclinical …
M Segovia-Mendoza… - American journal of …, 2015 - ncbi.nlm.nih.gov
An increasing number of tumors, including breast cancer, overexpress proteins of the
epidermal growth factor receptor (EGFR) family. The interaction between family members …
epidermal growth factor receptor (EGFR) family. The interaction between family members …
[HTML][HTML] Reduced exosome miR-425 and miR-744 in the plasma represents the progression of fibrosis and heart failure
L Wang, J Liu, B Xu, YL Liu, Z Liu - The Kaohsiung journal of medical …, 2018 - Elsevier
Heart failure creates a leading public health burden worldwide and cardiac fibrosis is a
hallmark of pathological cardiac remodeling which was found in HF patients. In this study …
hallmark of pathological cardiac remodeling which was found in HF patients. In this study …
MicroRNA expression profiling in placenta and maternal plasma in early pregnancy loss
MK Hosseini, T Gunel… - Molecular …, 2018 - spandidos-publications.com
Early pregnancy loss (EPL), also termed early miscarriage, is determined as the
unintentional expulsion of an embryo or fetus prior to the 12th week of gestation. EPL …
unintentional expulsion of an embryo or fetus prior to the 12th week of gestation. EPL …
High expression of microRNA-143 is associated with favorable tumor immune microenvironment and better survival in estrogen receptor positive breast cancer
microRNA-143 (miR-143) is a well-known tumor suppressive microRNA that exhibits anti-
tumoral function by targeting KRAS signaling pathways in various malignancies. We …
tumoral function by targeting KRAS signaling pathways in various malignancies. We …
[HTML][HTML] MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1
FY Xie, S Hosany, S Zhong, Y Jiang, F Zhang, LL Lin… - PloS one, 2017 - journals.plos.org
In many cancers, microRNA-193a (miR-193a) is a suppressor miRNA, but its underlying anti-
oncogenic activity in breast cancer is not known. In this study, we found decreased miR …
oncogenic activity in breast cancer is not known. In this study, we found decreased miR …
[HTML][HTML] Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients
T Xu, Q Zhou, L Che, S Das, L Wang, J Jiang, G Li… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Congestive heart failure (CHF) is a major cause of hospitalizations, morbidity, and mortality
in Western societies. In addition to optimal medical and device therapy, exercise training is …
in Western societies. In addition to optimal medical and device therapy, exercise training is …
Biosynthesis and biomedical perspectives of carotenoids with special reference to human health-related applications
Carotenoids are a group of versatile isoprenoid pigments, and bioactive constituents found
predominantly in fruits and vegetables. Carotenoids play an essential role in the prevention …
predominantly in fruits and vegetables. Carotenoids play an essential role in the prevention …
Plasma miRNA levels for predicting therapeutic response to neoadjuvant treatment in HER2-positive breast cancer: Results from the NeoALTTO trial
S Di Cosimo, V Appierto, S Pizzamiglio, P Tiberio… - Clinical cancer …, 2019 - AACR
Purpose: To investigate the potential of circulating-miRNAs (ct-miRNA) as noninvasive
biomarkers to predict the efficacy of single/dual HER2-targeted therapy in the NeoALTTO …
biomarkers to predict the efficacy of single/dual HER2-targeted therapy in the NeoALTTO …
[HTML][HTML] Prognostic role of microRNAs in breast cancer: A systematic review
E Zografos, F Zagouri, D Kalapanida, R Zakopoulou… - Oncotarget, 2019 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) have been found to play an important role in breast cancer,
functioning either as potential oncogenes or tumor suppressor genes, but their role in the …
functioning either as potential oncogenes or tumor suppressor genes, but their role in the …