The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

In spite of important advances in cardiology in recent years, pharmacological control
ofcardiac arrhythmias in the clinic remains an experiment conducted on a patient-by-patient …

The mechanisms underlying many important properties of the human atrial action potential
(AP) are poorly understood. Using specific formulations of the K+, Na+, and Ca2+ currents …

Membrane current abnormalities have been described in human heart failure. To determine
whether similar current changes are observed in a large animal model of heart failure, we …

In the mammalian heart, Ca2+‐independent, depolarization‐activated potassium (K+)
currents contribute importantly to shaping the waveforms of action potentials, and several …

Background Recordings of outward currents in human ventricular myocytes revealed the
presence of a large calcium-insensitive transient outward current. This current has been …

1. In rabbit and human hearts there are significant differences in the action potential
configuration in atrium and ventricle, and the action potential waveform exhibits marked …

Rapidly activating and inactivating cardiac transient outward K+ currents, Ito, are expressed
in most mammalian cardiomyocytes, and contribute importantly to the early phase of action …

1. Regional variations in the shape of early repolarization of the action potential have been
correlated to differences in transient outward K+ current, I (t), in myocytes isolated from the …

Depolarization-activated outward K+ currents in isolated adult rat ventricular myocytes were
characterized using the whole-cell variation of the patch-clamp recording technique. During …