Simple Summary Metastasis, the process by which cancer cells escape primary tumor site
and colonize distant organs, is responsible for most cancer-related deaths. The tumor …

Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

Matrix metalloproteinases (MMPs) or matrixins, are members of a zinc-dependent
endopeptidase family. They cause remodeling of the extracellular matrix (ECM) leading to …

Proteoglycans are major constituents of extracellular matrices, as well as cell surfaces and
basement membranes. They play key roles in supporting the dynamic extracellular matrix by …

The biological functions of estrogens are regulated by estrogen receptors (ERα and ERβ),
which contribute in the progression of several hormone-responsive cancer types via …

Breast cancer is defined as a cancer originating in tissues of the breast, frequently in ducts
and lobules. During the last 30 years, studies to understand the biology and to treat breast …

Diabetic bone disease (DBD) is a frequent complication in patients with type 2 diabetes
mellitus (T2DM), characterised by altered bone mineral density (BMD) and bone turnover …

As the primary cause of death for> 90% of cancers, metastasis is the fourth and final stage of
cancer during which cells gain the ability to leave their primary site, invade surrounding …

Zoledronic acid is regarded as the most potent bisphosphonate and is widely used in
patients with osteoporosis; however, its side effects, including acute‑phase reactions …

Unlike other antiresorptive medications, bisphosphonate molecules accumulate in the bone
matrix. Previous studies of side-effects of anti-resorptive treatment focused mainly on …