Deciphering the assembly of enveloped viruses using model lipid membranes
E Brémaud, C Favard, D Muriaux - Membranes, 2022 - mdpi.com
The cell plasma membrane is mainly composed of phospholipids, cholesterol and
embedded proteins, presenting a complex interface with the environment. It maintains a …
embedded proteins, presenting a complex interface with the environment. It maintains a …
The interplay between HIV-1 Gag binding to the plasma membrane and Env incorporation
RE Murphy, JS Saad - Viruses, 2020 - mdpi.com
Advancement in drug therapies and patient care have drastically improved the mortality
rates of HIV-1 infected individuals. Many of these therapies were developed or improved …
rates of HIV-1 infected individuals. Many of these therapies were developed or improved …
Maturation of the matrix and viral membrane of HIV-1
K Qu, Z Ke, V Zila, M Anders-Össwein, B Glass… - Science, 2021 - science.org
Gag, the primary structural protein of HIV-1, is recruited to the plasma membrane for virus
assembly by its matrix (MA) domain. Gag is subsequently cleaved into its component …
assembly by its matrix (MA) domain. Gag is subsequently cleaved into its component …
HIV-1 Gag specifically restricts PI (4, 5) P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly
HIV-1 Gag protein assembles at the plasma membrane of infected cells for viral particle
formation. Gag targets lipids, mainly PI (4, 5) P2, at the inner leaflet of this membrane. Here …
formation. Gag targets lipids, mainly PI (4, 5) P2, at the inner leaflet of this membrane. Here …
HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization
The HIV-1 virion structural polyprotein, Gag, is directed to particle assembly sites at the
plasma membrane by its N-terminal matrix (MA) domain. MA also binds to host tRNAs. To …
plasma membrane by its N-terminal matrix (MA) domain. MA also binds to host tRNAs. To …
Human Immunodeficiency Virus Type 1 Gag Polyprotein Modulates Membrane Physical Properties like a Surfactant: Potential Implications for Virus Assembly
ZG Denieva, PI Kuzmin, TR Galimzyanov… - ACS Infectious …, 2024 - ACS Publications
Human immunodeficiency virus (HIV) assembly at an infected cell's plasma membrane
requires membrane deformation to organize the near-spherical shape of an immature virus …
requires membrane deformation to organize the near-spherical shape of an immature virus …
Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes
Human immunodeficiency virus type 1 (HIV-1) acquires its lipid envelope during budding
from the plasma membrane of the host cell. Various studies indicated that HIV-1 membranes …
from the plasma membrane of the host cell. Various studies indicated that HIV-1 membranes …
Atomic view of the HIV-1 matrix lattice; implications on virus assembly and envelope incorporation
During the late phase of HIV type 1 (HIV-1) infection cycle, the virally encoded Gag
polyproteins are targeted to the inner leaflet of the plasma membrane (PM) for assembly …
polyproteins are targeted to the inner leaflet of the plasma membrane (PM) for assembly …
Self assembly of HIV-1 Gag protein on lipid membranes generates PI(4,5)P2/Cholesterol nanoclusters
The self-assembly of HIV-1 Gag polyprotein at the inner leaflet of the cell host plasma
membrane is the key orchestrator of virus assembly. The binding between Gag and the …
membrane is the key orchestrator of virus assembly. The binding between Gag and the …
A clue to unprecedented strategy to HIV eradication:“Lock-in and apoptosis”
H Tateishi, K Monde, K Anraku, R Koga, Y Hayashi… - Scientific Reports, 2017 - nature.com
Despite the development of antiretroviral therapy against HIV, eradication of the virus from
the body, as a means to a cure, remains in progress. A “kick and kill” strategy proposes “kick” …
the body, as a means to a cure, remains in progress. A “kick and kill” strategy proposes “kick” …