Chalcones as putative hepatoprotective agents: Preclinical evidence and molecular mechanisms
E Karimi-Sales, G Mohaddes, MR Alipour - Pharmacological research, 2018 - Elsevier
Chalcones form an important group of natural compounds and flavonoid precursors which
are abundant in fruits, vegetables, and edible plants. These compounds have many …
are abundant in fruits, vegetables, and edible plants. These compounds have many …
Role of nutraceuticals in COVID-19 mediated liver dysfunction
COVID-19 is known as one of the deadliest pandemics of the century. The rapid spread of
this deadly virus at incredible speed has stunned the planet and poses a challenge to global …
this deadly virus at incredible speed has stunned the planet and poses a challenge to global …
trans-Chalcone modulates Leishmania amazonensis infection in vitro by Nrf2 overexpression affecting iron availability
MM Miranda-Sapla, F Tomiotto-Pellissier… - European Journal of …, 2019 - Elsevier
Leishmania parasites infect macrophages causing a wide spectrum of human diseases
encompassing from cutaneous to visceral forms. The drugs currently used in leishmaniasis …
encompassing from cutaneous to visceral forms. The drugs currently used in leishmaniasis …
trans-Chalcone, a flavonoid precursor, inhibits UV-induced skin inflammation and oxidative stress in mice by targeting NADPH oxidase and cytokine production
RM Martinez, FA Pinho-Ribeiro, VS Steffen… - Photochemical & …, 2017 - Springer
Abstract trans-Chalcone is a plant flavonoid precursor, which lacks broad investigation on its
biological activity in inflammatory processes. In the present study, anti-inflammatory and …
biological activity in inflammatory processes. In the present study, anti-inflammatory and …
Novel mechanistic insight into the anticancer activity of cucurbitacin D against pancreatic cancer (Cuc D attenuates pancreatic cancer)
Pancreatic cancer (PanCa) is one of the leading causes of death from cancer in the United
States. The current standard treatment for pancreatic cancer is gemcitabine, but its success …
States. The current standard treatment for pancreatic cancer is gemcitabine, but its success …
Chalcone derivatives 4′-amino-1-naphthyl-chalcone (D14) and 4′-amino-4-methyl-1-naphthyl-chalcone (D15) suppress migration and invasion of osteosarcoma …
Osteosarcoma (OS) is a primary malignant bone tumor that mainly affects children,
adolescents, and young adults. The inhibition of metastasis is a main strategy of OS therapy …
adolescents, and young adults. The inhibition of metastasis is a main strategy of OS therapy …
Development of trans-Chalcone loaded pectin/casein biodegradable microcapsules: Efficacy improvement in the management of experimental colitis
CFS Guazelli, V Fattori, BB Colombo, IS Ludwig… - International Journal of …, 2023 - Elsevier
Improved therapies for inflammatory bowel diseases are sorely needed. Novel therapeutic
agents and the development of controlled release systems for targeted tissue delivery are …
agents and the development of controlled release systems for targeted tissue delivery are …
Hepatoprotective effect of trans-Chalcone on experimentally induced hepatic injury in rats: inhibition of hepatic inflammation and fibrosis
The current study investigated the hepatoprotective effect of trans-Chalcone in carbon
tetrachloride (CCl4) and paracetamol (PCM) induced liver damage in rats. Administration of …
tetrachloride (CCl4) and paracetamol (PCM) induced liver damage in rats. Administration of …
[HTML][HTML] Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice
RM Martinez, FA Pinho-Ribeiro, DL Vale… - … of Photochemistry and …, 2017 - Elsevier
Trans-chalcone (TC) is a common precursor of flavonoids. However, the pharmacological
properties of TC remain to be fully understood. The present study investigated whether …
properties of TC remain to be fully understood. The present study investigated whether …
Chalcone-induced apoptosis through caspase-dependent intrinsic pathways in human hepatocellular carcinoma cells
R Ramirez-Tagle, CA Escobar, V Romero… - International Journal of …, 2016 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers
worldwide. Chemoprevention of HCC can be achieved through the use of natural or …
worldwide. Chemoprevention of HCC can be achieved through the use of natural or …