Biosensing with dnazymes

EM McConnell, I Cozma, Q Mou, JD Brennan… - Chemical Society …, 2021 - pubs.rsc.org
This article provides a comprehensive review of biosensing with DNAzymes, providing an
overview of different sensing applications while highlighting major progress and seminal …

Therapeutic DNAzymes: from structure design to clinical applications

J Yan, M Ran, X Shen, H Zhang - Advanced Materials, 2023 - Wiley Online Library
Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their
prosperous gene regulation capability. The efficacy of DNAzymes against many types of …

An autocatalytic multicomponent DNAzyme nanomachine for tumor-specific photothermal therapy sensitization in pancreatic cancer

J Yan, X Ma, D Liang, M Ran, D Zheng, X Chen… - Nature …, 2023 - nature.com
Multicomponent deoxyribozymes (MNAzymes) have great potential in gene therapy, but
their ability to recognize disease tissue and further achieve synergistic gene regulation has …

Identification of antibiotic resistance in ESKAPE pathogens through plasmonic nanosensors and machine learning

T Yu, Y Fu, J He, J Zhang, Y Xianyu - ACS nano, 2023 - ACS Publications
Antibiotic-resistant ESKAPE pathogens cause nosocomial infections that lead to huge
morbidity and mortality worldwide. Rapid identification of antibiotic resistance is vital for the …

Machine learning-assisted optical nano-sensor arrays in microorganism analysis

J Yang, S Lu, B Chen, F Hu, C Li, C Guo - TrAC Trends in Analytical …, 2023 - Elsevier
Microbial infection can cause problems for public health, and to realize efficient
microorganism detection is of great importance. However, the simultaneous identification of …

Aptamer-based colorimetric detection of methicillin-resistant Staphylococcus aureus by using a CRISPR/Cas12a system and recombinase polymerase amplification

L Wei, Z Wang, J Wang, X Wang, Y Chen - Analytica Chimica Acta, 2022 - Elsevier
Detection of methicillin-resistant Staphylococcus aureus (MRSA) with superior accuracy,
timeliness, and simplicity is highly valuable in clinical diagnosis and food safety. In this …

Ratiometric fluorescence detection of tetracycline for tetracycline adjuvant screening in bacteria

S Zhang, Q Sun, X Liu, H Li, J Wang, M Chen - Sensors and Actuators B …, 2022 - Elsevier
Persistent generation of tetracycline (TC) resistant bacteria poses serious risks for public
health. It is of great importance to develop a strategy for rapid screening TC adjuvants for …

Wearable, Biocompatible, and Dual-Emission Ocular Multisensor Patch for Continuous Profiling of Fluoroquinolone Antibiotics in Tears

S Yin, X Chen, R Li, L Sun, C Yao, Z Li - ACS nano, 2024 - ACS Publications
The abuse or misuse of antibiotics in clinical and agricultural settings severely endangers
human health and ecosystems, which has raised profound concerns for public health …

Chemical and structural modification of RNA-cleaving DNAzymes for efficient biosensing and biomedical applications

Q Wang, Z Wang, Y He, B Xiong, Y Li… - TrAC Trends in Analytical …, 2023 - Elsevier
Deoxyribozyme (DNAzyme) is single-stranded catalytic DNA that possesses various
physical and chemical features, including small molecular weight, higher stability, excellent …

Antibiotic resistance mechanism and diagnosis of common foodborne pathogens based on genotypic and phenotypic biomarkers

X Liao, R Deng, K Warriner… - Comprehensive Reviews in …, 2023 - Wiley Online Library
The emergence of antibiotic‐resistant bacteria due to the overuse or inappropriate use of
antibiotics has become a significant public health concern. The agri‐food chain, which …