Exploring the complex relationship between diabetes and cardiovascular complications: understanding diabetic cardiomyopathy and promising therapies

N Ghosh, L Chacko, H Bhattacharya, J Vallamkondu… - Biomedicines, 2023 - mdpi.com
Diabetes mellitus (DM) and cardiovascular complications are two unmet medical
emergencies that can occur together. The rising incidence of heart failure in diabetic …

Molecular mechanisms of sacubitril/valsartan in cardiac remodeling

NH Mustafa, J Jalil, S Zainalabidin… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular diseases have become a major clinical burden globally. Heart failure is one
of the diseases that commonly emanates from progressive uncontrolled hypertension. This …

miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with …

SS Jankauskas, P Mone, R Avvisato, F Varzideh… - Mechanisms of ageing …, 2023 - Elsevier
Background Cardiac fibrosis represents a key element in the pathophysiology of heart
failure with preserved ejection fraction (HFpEF), a condition highly prevalent amongst …

Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery

S Gao, X Liu, T Li, L Chen, Y Feng, Y Wang… - Acta Pharmacologica …, 2024 - nature.com
Heart failure (HF) with preserved ejection fraction (HFpEF) is currently a preeminent
challenge for cardiovascular medicine. It has a poor prognosis, increasing mortality, and is …

Reducing Cardiac Steatosis: Interventions to Improve Diastolic Function: A Narrative Review

K Heshmat-Ghahdarijani, R Modaresi… - Current Problems in …, 2023 - Elsevier
Heart failure is one of the main causes of morbidity and mortality around the globe. Heart
failure with preserved ejection fraction is primarily caused by diastolic dysfunction. Adipose …

Neprilysin inhibition in the prevention of anthracycline-induced cardiotoxicity

AM Sobiborowicz-Sadowska, K Kamińska… - Cancers, 2023 - mdpi.com
Simple Summary Anthracycline-induced cardiotoxicity (AIC) poses a significant clinical
challenge in the management of cancer patients. Thus, the development of effective …

Angiotensin receptor–neprilysin inhibitors for hypertension—hemodynamic effects and relevance to hypertensive heart disease

K Kario, B Williams - Hypertension Research, 2022 - nature.com
Angiotensin receptor–neprilysin inhibitors have multiple beneficial effects on the
cardiovascular system. The angiotensin receptor–neprilysin inhibitor sacubitril/valsartan has …

Obesity: The perfect storm for heart failure

M Lembo, T Strisciuglio, C Fonderico… - ESC Heart …, 2024 - Wiley Online Library
Obesity condition causes morphological and functional alterations involving the
cardiovascular system. These can represent the substrates for different cardiovascular …

[HTML][HTML] Sacubitril/valsartan attenuates myocardial inflammation, hypertrophy, and fibrosis in rats with heart failure with preserved ejection fraction

YJ Shi, CG Yang, WB Qiao, YC Liu, SY Liu… - European Journal of …, 2023 - Elsevier
Heart failure with preserved ejection fraction (HFpEF) represents a multifaceted syndrome
related to complex pathologic mechanisms. Sacubitril/valsartan (Sac/val) has demonstrated …

Association between arterial stiffness and heart failure with preserved ejection fraction

C Chi, Y Liu, Y Xu, D Xu - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Cardiovascular diseases are the leading cause of mortality in the world. Heart failure with
preserved ejection fraction (HFpEF) accounts for about half of all heart failure. Unfortunately …