Hemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the
emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) …

Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally
been neglected as tropical diseases primarily affecting African and South American regions …

Innate immune cells are critical in protective immunity against viral infections, involved in
sensing foreign viral nucleic acids. Here we report that the poly (ADP-ribose) polymerase 9 …

Many double-stranded DNA viruses, such as Epstein-Barr virus, can establish persistent
infection, but the underlying virus–host interactions remain poorly understood. Here we …

Background Infections by viruses including severe acute respiratory syndrome coronavirus 2
could cause organ inflammations such as myocarditis, pneumonia and encephalitis. Innate …

RNA helicases play critical roles in various biological processes, including serving as viral
RNA sensors in innate immunity. Here, we find that RNA helicase DEAH-box helicase 15 …

Infections by enteric virus and intestinal inflammation are recognized as a leading cause of
deadly gastroenteritis, and NLRP6 and NLRP9b signaling control these infection and …

The innate immunity is critically important in protection against virus infections, and in the
case of RNA viral infections, the signaling mechanisms that initiate robust protective innate …

Mammalian arenaviruses are zoonotic viruses that cause asymptomatic, persistent
infections in their rodent hosts but can lead to severe and lethal hemorrhagic fever with …

Macrophages (Mφ) are innate immune cells with a variety of functional phenotypes
depending on the cytokine microenvironment they reside in. Mφ exhibit distinct activation …