Biological systems have evolved to harness non-equilibrium processes from the molecular
to the macro scale. It is currently a grand challenge of chemistry, materials science, and …

The microtubule (MT) cytoskeleton supports a broad range of cellular functions, from
providing tracks for intracellular transport, to supporting movement of cilia and flagella, to …

Our knowledge of disease genes in neurological disorders is incomplete. With the aim of
closing this gap, we performed whole-exome sequencing on 143 multiplex consanguineous …

We have created FtsZ‐YFP‐mts where an amphipathic helix on the C‐terminus tethers FtsZ
to the membrane. When incorporated inside multi‐lamellar tubular liposomes, FtsZ‐YFP‐mts …

Kinesin-8s are dual-activity motor proteins that can move processively on microtubules and
depolymerize microtubule plus-ends, but their mechanism of combining these distinct …

Recent technical advances have dramatically increased the power and scope of structural
biology. New developments in high-resolution cryo-electron microscopy, serial X-ray …

In eukaryotes, the dynamic assembly of microtubules (MT) plays an important role in
numerous cellular processes. The underlying mechanism of GTP triggering MT assembly is …

Kinesin-13 proteins are major microtubule (MT) regulatory factors that catalyze removal of
tubulin subunits from MT ends. The class-specific “neck” and loop 2 regions of these motors …

Kinesin-13s constitute a distinct group within the kinesin superfamily of motor proteins that
promote microtubule depolymerization and lack motile activity. The molecular mechanism by …

Microtubules, the most rigid components of the cytoskeleton, can be key transduction
elements between external forces and the cellular environment. Mechanical forces induce …