Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …

Autoimmune diseases are characterized by the body's own immune system attack to the self-
tissues, a condition enabled, in predisposed subjects, by the reduction of self-tolerance. A …

Peptidylarginine deiminases, or PADs, convert arginine residues to the non-ribosomally
encoded amino acid citrulline in a variety of protein substrates. PAD4 is expressed in …

The global COVID-19 pandemic has the potential to severely affect those with rheumatic
diseases or who are taking immunosuppressive therapies. Information is lacking as to how …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by autoantibodies
against citrullinated antigens. The importance of citrulline for the epitopes bound by these …

Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of
rheumatoid arthritis (RA) owing to their ability to generate citrullinated proteins—the …

In response to inflammation, neutrophils deiminate histones and externalize chromatin.
Neutrophil extracellular traps (NETs) are an innate immune defense mechanism, yet NETs …

Background Rheumatoid arthritis (RA) is characterised by autoimmunity to citrullinated
proteins, and there is increasing epidemiologic evidence linking Porphyromonas gingivalis …

The post‐translational modification of histones has significant effects on overall chromatin
function. One such modification is citrullination, which is catalyzed by the protein arginine …

Autoantibodies to citrullinated protein antigens are specific markers of rheumatoid arthritis
(RA). Although protein citrullination can be activated by numerous stimuli in cells, it remains …