Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

The Janus kinase/signal transducer and activator of transcription (Jak/Stat) pathway was
discovered 20 years ago as a mediator of cytokine signaling. Since this time, more than …

Aberrant epidermal growth factor receptor (EGFR) signaling is common in cancer. Increased
expression of wild type and mutant EGFR is a widespread feature of diverse types of cancer …

Simple Summary Glioblastoma is one of the most treatment-refractory human malignancies,
and despite techniques that have allowed scientists and clinicians to better understand the …

Signal transducer and activator of transcription 3 (STAT3) regulates diverse cellular
processes, including cell growth, differentiation, and apoptosis, and is frequently activated …

Signal transducer and activator of transcription (STAT) 3 is a key signalling protein engaged
by a multitude of growth factors and cytokines to elicit diverse biological outcomes including …

The mammalian target of rapamycin (mTOR) pathway regulates major processes by
integrating a variety of exogenous cues, including diverse environmental inputs in the tumor …

Identifying putative biomarkers of clinical outcomes in cancer is crucial for successful
enrichment, and for the selection of patients who are the most likely to benefit from a specific …

Despite considerable amount of research, the poor prognosis of patients diagnosed with
glioblastoma multiforme (GBM) critically needs new drug development to improve clinical …

Signal transducer and activator of transcription 3 (STAT3) regulates many critical functions in
human normal and malignant tissues, such as differentiation, proliferation, survival …