DNA sequencing data continue to progress toward longer reads with increasingly lower
sequencing error rates. Here, we define an algorithmic approach, mdBG, that makes use of …

Diploidy has profound implications for population genetics and susceptibility to genetic
diseases. Although two copies are present for most genes in the human genome, they are …

High-throughput sequencing provides sufficient means for determining genotypes of
clinically important pharmacogenes that can be used to tailor medical decisions to individual …

Pharmacogenetic tests typically target selected sequence variants to identify haplotypes that
are often defined by star (∗) allele nomenclature. Due to their design, these targeted …

Fig. 1| The Seq programming language. a, Conceptual comparison of Seq, python and C++.
Seq combines the high performance of C++ with the programming ease and clarity of …

Directed evolution can generate proteins with tailor-made activities. However, full-length
genotypes, their frequencies and fitnesses are difficult to measure for evolving gene-length …

By employing single charge injections with an atomic force microscope, we investigated
redox reactions of a molecule on a multilayer insulating film. First, we charged the molecule …

Linked-read sequencing promises a one-method approach for genome-wide insights
including single nucleotide variants (SNVs), structural variants, and haplotyping. We …

Human DNA sequencing protocols have revolutionized human biology, biomedical science,
and clinical practice, but still have very important limitations. One limitation is that most …

Introduction Cell entry of SARS-CoV-2 causes genome-wide disruption of the transcriptional
profiles of genes and biological pathways involved in the pathogenesis of COVID-19 …