The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

Covering: 2015 to the end of 2020 Fungal-derived polyketides, non-ribosomal peptides,
terpenoids and their hybrids contribute significantly to the chemical space of total natural …

Chimeric terpene synthases, which consist of C-terminal prenyltransferase (PT) and N-
terminal class I terpene synthase (TS) domains (termed PTTSs here), is unique to fungi and …

Covering: 2000 to 2018 In the late 1960s, structurally unique fusicoccane-and ophiobolane-
type di/sesterterpenes were isolated and their homologs were found to be widely distributed …

Terpenes, especially volatile terpenes, are important components of tea aroma due to their
unique scents. They are also widely used in the cosmetic and medical industries. In addition …

Sesterterpenoids are a rare terpene class harboring untapped chemodiversity and
bioactivities. Their structural diversity originates primarily from the scaffold-generating …

The mechanisms of two diterpene cyclases from streptomycetes—one with an unknown
product that was identified as the spirocyclic hydrocarbon spiroviolene and one with the …

Covering: July 2012 to December 2019 Over the last seven years, expanding research
efforts focused on sesterterpenoids has led to the isolation, identification, and …

Covering: up to August 2023Terpenoids, which are widely distributed in animals, plants, and
microorganisms, are a large group of natural products with diverse structures and various …

Covering: 1969 up to 2021 Sesterterpenoids, biosynthetically derived from the precursor,
namely geranylfarnesyl diphosphate (GFDP) are amongst the rarest of all isoprenoids with …