Disorders of the immune system, including immunodeficiency, immuno-malignancy, and
(auto) inflammatory, autoimmune, and allergic diseases, have a great impact on a host's …

Neural circuit assembly in the brain requires precise establishment of synaptic connections,
but the mechanisms of synapse assembly remain incompletely understood. Latrophilins are …

Adhesion G protein-coupled receptors (aGPCRs) are a large GPCR class that direct diverse
fundamental biological processes. One prominent mechanism for aGPCR agonism involves …

Adhesion GPCRs are important regulators of conserved developmental processes and
represent an untapped pool of potential targets for drug discovery. The adhesion GPCR …

GPR133 (ADGRD1), an adhesion G protein–coupled receptor (GPCR) whose canonical
signaling activates G αS-mediated generation of cytosolic cAMP, has been shown to be …

Brain-specific angiogenesis inhibitor 1 (BAI1; also called ADGRB1 or B1) is an adhesion G
protein–coupled receptor known from studies on macrophages to bind to phosphatidylserine …

Aims TAFA2, a cytokine specifically expressed in the central nervous system, plays a vital
role in neuronal cell survival. TAFA2 deficiency has been correlated to various neurological …

Background Glioma is a family of primary brain malignancies with limited treatment options
and in need of novel therapies. We previously demonstrated that the adhesion G protein …

Teneurin C-terminal associated peptides (TCAP) are natural bioactive peptides that possess
anxiety-reducing roles in animals, in vivo, and increase cell viability, in vitro. Although these …

Adhesion G protein-coupled receptors (ADGRGs) play critical roles in the reproductive,
neurological, cardiovascular, and endocrine systems. In particular, ADGRG2 plays a …