Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism

D Burstein, TC Griffen, K Therrien, J Bendl… - Nature …, 2023 - nature.com
Binge eating disorder (BED) is the most common eating disorder, yet its genetic architecture
remains largely unknown. Studying BED is challenging because it is often comorbid with …

Strategies for the genomic analysis of admixed populations

T Tan, EG Atkinson - Annual review of biomedical data science, 2023 - annualreviews.org
Admixed populations constitute a large portion of global human genetic diversity, yet they
are often left out of genomics analyses. This exclusion is problematic, as it leads to …

Quantitative human paleogenetics: what can ancient DNA tell us about complex trait evolution?

EK Irving-Pease, R Muktupavela, M Dannemann… - Frontiers in …, 2021 - frontiersin.org
Genetic association data from national biobanks and large-scale association studies have
provided new prospects for understanding the genetic evolution of complex traits and …

Genotyping and population characteristics of the China Kadoorie Biobank

RG Walters, IY Millwood, K Lin, DS Valle, P McDonnell… - Cell Genomics, 2023 - cell.com
Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …

Wrestling with social and behavioral genomics: risks, potential benefits, and ethical responsibility

MN Meyer, PS Appelbaum, DJ Benjamin… - Hastings Center …, 2023 - Wiley Online Library
In this consensus report by a diverse group of academics who conduct and/or are concerned
about social and behavioral genomics (SBG) research, the authors recount the often‐ugly …

Analysis of genetic dominance in the UK Biobank

DS Palmer, W Zhou, L Abbott, EM Wigdor, N Baya… - Science, 2023 - science.org
Classical statistical genetics theory defines dominance as any deviation from a purely
additive, or dosage, effect of a genotype on a trait, which is known as the dominance …

Shared genetic architectures of educational attainment in East Asian and European populations

TT Chen, J Kim, M Lam, YF Chuang, YL Chiu… - Nature Human …, 2024 - nature.com
Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive
ability, is associated with various health and social outcomes. Previous genome-wide …

The economics and econometrics of gene-environment interplay

P Biroli, TJ Galama, S von Hinke… - arXiv preprint arXiv …, 2022 - arxiv.org
Economists and social scientists have debated the relative importance of nature (one's
genes) and nurture (one's environment) for decades, if not centuries. This debate can now …

Trans-ancestry meta-analysis of genome wide association studies of inhibitory control

A Arnatkeviciute, M Lemire, C Morrison, M Mooney… - Molecular …, 2023 - nature.com
Deficits in effective executive function, including inhibitory control are associated with risk for
a number of psychiatric disorders and significantly impact everyday functioning. These …

Cross-ancestry genomic research: time to close the gap

EG Atkinson, SB Bianchi, GY Ye… - …, 2022 - nature.com
Genome-wide association studies (GWAS) have revolutionized our ability to understand the
genetic underpinnings of biomedical traits; however, their extreme Eurocentric bias has …