The role of ubiquitination in tumorigenesis and targeted drug discovery
Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
PROTAC: an effective targeted protein degradation strategy for cancer therapy
Proteolysis targeting chimeric (PROTAC) technology is an effective endogenous protein
degradation tool developed in recent years that can ubiquitinate the target proteins through …
degradation tool developed in recent years that can ubiquitinate the target proteins through …
MDM2 inhibitors for cancer therapy: the past, present, and future
W Wang, N Albadari, Y Du, JF Fowler, HT Sang… - Pharmacological …, 2024 - Elsevier
Since its discovery over 35 years ago, MDM2 has emerged as an attractive target for the
development of cancer therapy. MDM2's activities extend from carcinogenesis to immunity to …
development of cancer therapy. MDM2's activities extend from carcinogenesis to immunity to …
Regulating tumor suppressor genes: post-translational modifications
L Chen, S Liu, Y Tao - Signal transduction and targeted therapy, 2020 - nature.com
Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …
Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update
The presence of multidrug resistance (MDR) in malignant tumors is one of the primary
causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …
causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …
Propofol protects myocardium from ischemia/reperfusion injury by inhibiting ferroptosis through the AKT/p53 signaling pathway
S Li, Z Lei, X Yang, M Zhao, Y Hou, D Wang… - Frontiers in …, 2022 - frontiersin.org
The molecular mechanism underlying the protective role of propofol against myocardial
ischemia/reperfusion (I/R) injury remains poorly understood. Previous studies have shown …
ischemia/reperfusion (I/R) injury remains poorly understood. Previous studies have shown …
MDM2 amplified sarcomas: a literature review
R Sciot - Diagnostics, 2021 - mdpi.com
Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an
oncoprotein of which the association with p53 was discovered 30 years ago. The most …
oncoprotein of which the association with p53 was discovered 30 years ago. The most …
Targeting USP7-mediated deubiquitination of MDM2/MDMX-p53 pathway for cancer therapy: are we there yet?
SM Qi, G Cheng, XD Cheng, Z Xu, B Xu… - Frontiers in cell and …, 2020 - frontiersin.org
The p53 tumor suppressor protein and its major negative regulators MDM2 and MDMX
oncoproteins form the MDM2/MDMX-p53 circuitry, which plays critical roles in regulating …
oncoproteins form the MDM2/MDMX-p53 circuitry, which plays critical roles in regulating …
Emerging therapeutic approaches to target the dark side of senescent cells: new hopes to treat aging as a disease and to delay age-related pathologies
R Khalil, M Diab-Assaf, JM Lemaitre - Cells, 2023 - mdpi.com
Life expectancy has drastically increased over the last few decades worldwide, with
important social and medical burdens and costs. To stay healthy longer and to avoid chronic …
important social and medical burdens and costs. To stay healthy longer and to avoid chronic …
Ferroptosis—a new dawn in the treatment of organ ischemia–reperfusion injury
L Zhou, S Han, J Guo, T Qiu, J Zhou, L Shen - Cells, 2022 - mdpi.com
Ischemia–reperfusion (I/R) is a common pathological phenomenon that occurs in numerous
organs and diseases. It generally results from secondary damage caused by the recovery of …
organs and diseases. It generally results from secondary damage caused by the recovery of …