Impact of stabilizing mutations on the antigenic profile and glycosylation of membrane-expressed HIV-1 envelope glycoprotein
T Tong, A D'Addabbo, J Xu, H Chawla… - PLoS …, 2023 - journals.plos.org
Recent HIV-1 vaccine development has centered on “near native” soluble envelope
glycoprotein (Env) trimers that are artificially stabilized laterally (between protomers) and …
glycoprotein (Env) trimers that are artificially stabilized laterally (between protomers) and …
V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins
ABSTRACT CD4-mimetic compounds (CD4mcs) bind the human immunodeficiency virus
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …
Global increases in human immunodeficiency virus neutralization sensitivity due to alterations in the membrane-proximal external region of the envelope glycoprotein …
Binding to the receptor, CD4, drives the pretriggered,“closed”(State-1) conformation of the
human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer ([gp120/gp41] 3) …
human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer ([gp120/gp41] 3) …
Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens
ET Crooks, F Almanza, A D'addabbo, E Duggan… - PLoS …, 2021 - journals.plos.org
HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive
neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident …
neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident …
Subtle longitudinal alterations in Env sequence potentiate differences in sensitivity to broadly neutralizing antibodies following acute HIV-1 subtype C infection
T Mandizvo, N Gumede, B Ndlovu, S Ndlovu… - Journal of …, 2022 - Am Soc Microbiol
Broadly neutralizing antibodies (bNAbs) for HIV-1 prevention or cure strategies must inhibit
transmitted/founder and reservoir viruses. Establishing sensitivity of circulating viruses to …
transmitted/founder and reservoir viruses. Establishing sensitivity of circulating viruses to …
The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope
The sequence space accessible to evolving proteins can be enhanced by cellular
chaperones that assist biophysically defective clients in navigating complex folding …
chaperones that assist biophysically defective clients in navigating complex folding …
Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env
HM Schapiro, MD Khasnis, K Ahn, A Karagiaridi… - PLoS …, 2022 - journals.plos.org
Glycoprotein Env of human immunodeficiency virus type 1 (HIV-1) mediates viral entry
through membrane fusion. Composed of gp120 and gp41 subunits arranged as a trimer-of …
through membrane fusion. Composed of gp120 and gp41 subunits arranged as a trimer-of …
Impact of Common Modifications on the Antigenic Profile and Glycosylation of Membrane-Expressed HIV-1 Envelope Glycoprotein
T Tong, A D'Addabbo, J Xu, H Chalwa, A Nguyen… - bioRxiv, 2023 - biorxiv.org
Recent HIV-1 vaccine development has centered on “near native” soluble envelope
glycoprotein (Env) trimers. These trimers are artificially stabilized laterally (between …
glycoprotein (Env) trimers. These trimers are artificially stabilized laterally (between …
Variations in Env at amino acids 328 and 330 affect HIV-1 replicative fitness and entry inhibitor sensitivity
H Wang, Y Li, Y Li, B Li, X Zhu, D Yan, M Li, W Wu… - Virus Research, 2021 - Elsevier
While the variations in the HIV-1 Env V3 loop have been the focus of much research to
explore its functional effect, how specific mutations of certain amino acids in the V3 loop …
explore its functional effect, how specific mutations of certain amino acids in the V3 loop …
Dissecting How Interactions at the Apex of HIV-1 Env Modulate Epitope Exposure at the Distant Base of the Glycoprotein
HM Schapiro - 2022 - search.proquest.com
The envelope glycoprotein, Env, of human immunodeficiency virus type 1 (HIV-1) mediates
viral entry through membrane fusion. Env is a structurally dynamic trimer consisting of three …
viral entry through membrane fusion. Env is a structurally dynamic trimer consisting of three …