Mass spectrometric epitope mapping has become a versatile method to precisely determine
a soluble antigen's partial structure that directly interacts with an antibody in solution. Typical …

Antibody drug conjugates (ADCs) are highly cytotoxic drugs covalently attached via
conditionally stable linkers to monoclonal antibodies (mAbs) and are among the most …

With the development of biomedical technology, epitope mapping of proteins has become
critical for developing and evaluating new protein drugs. The application of hydrogen …

Cashew plant (Anacardium occidentale L.) is the most relevant species of the Anacardium
genus. It presents high economic value since it is widely used in human nutrition and in …

The unique combinations of biological, nutritional and functional properties in proteins make
them important food ingredients with the capacity to provide a range of diverse and highly …

Immunoglobulin E (IgE)‐mediated food allergy is a rapidly growing public health problem.
The interaction between allergens and IgE is at the core of the allergic response. One of the …

Allergic reactions to food are among the major food safety concerns in industrialized
countries, and it is estimated that approximately 5% of the population suffers from …

Current approaches based on electrophoretic, chromatographic or immunochemical
principles have allowed characterizing multiple allergens, mapping their epitopes, studying …

A co-immobilized, dual protease column was developed and implemented to more efficiently
digest IgG molecules for hydrogen/deuterium exchange mass spectrometry (HDX-MS). The …

In vitro allergy diagnostics are currently based on the detection of specific IgE binding on
intact allergens or a mixture thereof. This approach has drawbacks as it may yield false …