Background In 2040, the older population's growth rate in sub-Saharan Africa (SSA) will be
faster than those experienced by developed nations since 1950. In preparation for this …

Primary open angle glaucoma (POAG) is a common late-onset neurodegenerative disease.
Ocular hypertension represents a major risk factor, but POAG etiology remains poorly …

Purpose.: Multiple genes have been associated with primary open angle glaucoma (POAG)
in Caucasian populations. We now examine the association of these loci in populations of …

Purpose To describe the baseline characteristics of the Primary Open-Angle African
American Glaucoma Genetics (POAAGG) study cohort, the largest African American …

Methods.: Primary open-angle glaucoma TM specimens were obtained from routine
trabeculectomy surgery. Nonglaucomatous control TM specimens were dissected from …

Rare variants of the olfactomedin domain of myocilin are considered causative for inherited,
early‐onset open‐angle glaucoma, with a misfolding toxic gain‐of‐function pathogenic …

Multiple loci have been associated with either primary open angle glaucoma (POAG) or
heritable ocular quantitative traits associated with this condition. This study examined the …

Background: The purpose of this study was to screen juvenile open angle glaucoma (JOAG)
patients from Brazil for variants within the MYOC and CYP1B1 genes. Material and Methods …

Accurate predictions of the pathogenicity of mutations associated with genetic diseases are
key to the success of precision medicine. Inherited missense mutations in the myocilin …

Purpose Juvenile onset primary open angle glaucoma (JOAG) is a rare disorder associated
with high IOP and progressive optic neuropathy in patients diagnosed before the age of 40 …