Role of immediate-early genes in synaptic plasticity and neuronal ensembles underlying the memory trace
K Minatohara, M Akiyoshi, H Okuno - Frontiers in molecular …, 2016 - frontiersin.org
In the brain, neuronal gene expression is dynamically changed in response to neuronal
activity. In particular, the expression of immediate-early genes (IEGs) such as egr-1, c-fos …
activity. In particular, the expression of immediate-early genes (IEGs) such as egr-1, c-fos …
Whole-body and whole-organ clearing and imaging techniques with single-cell resolution: toward organism-level systems biology in mammals
Organism-level systems biology aims to identify, analyze, control and design cellular circuits
in organisms. Many experimental and computational approaches have been developed …
in organisms. Many experimental and computational approaches have been developed …
Labelling and optical erasure of synaptic memory traces in the motor cortex
A Hayashi-Takagi, S Yagishita, M Nakamura, F Shirai… - Nature, 2015 - nature.com
Dendritic spines are the major loci of synaptic plasticity and are considered as possible
structural correlates of memory. Nonetheless, systematic manipulation of specific subsets of …
structural correlates of memory. Nonetheless, systematic manipulation of specific subsets of …
On-demand cell-autonomous gene therapy for brain circuit disorders
Several neurodevelopmental and neuropsychiatric disorders are characterized by
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …
Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations
CJ Guenthner, K Miyamichi, HH Yang, HC Heller… - Neuron, 2013 - cell.com
Targeting genetically encoded tools for neural circuit dissection to relevant cellular
populations is a major challenge in neurobiology. We developed an approach, targeted …
populations is a major challenge in neurobiology. We developed an approach, targeted …
Widespread transcription at neuronal activity-regulated enhancers
We used genome-wide sequencing methods to study stimulus-dependent enhancer function
in mouse cortical neurons. We identified∼ 12,000 neuronal activity-regulated enhancers …
in mouse cortical neurons. We identified∼ 12,000 neuronal activity-regulated enhancers …
Neuronal activity modifies the chromatin accessibility landscape in the adult brain
Neuronal activity-induced gene expression modulates the function and plasticity of the
nervous system. It is unknown whether and to what extent neuronal activity may trigger …
nervous system. It is unknown whether and to what extent neuronal activity may trigger …
Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression
Neuronal activation induces rapid transcription of immediate early genes (IEGs) and longer-
term chromatin remodeling around secondary response genes (SRGs). Here, we use high …
term chromatin remodeling around secondary response genes (SRGs). Here, we use high …
Functional connectivity of multiple brain regions required for the consolidation of social recognition memory
T Tanimizu, JW Kenney, E Okano… - Journal of …, 2017 - Soc Neuroscience
Social recognition memory is an essential and basic component of social behavior that is
used to discriminate familiar and novel animals/humans. Previous studies have shown the …
used to discriminate familiar and novel animals/humans. Previous studies have shown the …
Hippocampal somatostatin interneurons control the size of neuronal memory ensembles
T Stefanelli, C Bertollini, C Lüscher, D Muller… - Neuron, 2016 - cell.com
Hippocampal neurons activated during encoding drive the recall of contextual fear memory.
Little is known about how such ensembles emerge during acquisition and eventually form …
Little is known about how such ensembles emerge during acquisition and eventually form …