Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

The members of myocyte Enhancer Factor 2 (MEF2) protein family was previously believed
to function in the development of heart and muscle. Recent reports indicate that they are …

Objective Disruptions of extracellular matrix (ECM) homeostasis are key events in the
pathogenesis of osteoarthritis (OA). MicroRNA-140 (miRNA-140) is expressed specifically in …

Sustained and controllable local gene therapy is a potential method for treating osteoarthritis
(OA) through the delivery of therapeutic microRNAs (miRNAs) to targeted cells. However …

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. Heterozygous
loss-of-function point mutations of miRNA genes are associated with several human …

Osteoarthritis (OA) is a major cause of joint pain and disability, and chondrocyte senescence
is a key pathological process in OA and may be a target of new therapeutics. MicroRNA-140 …

Intervertebral disc degeneration (IDD) is associated with dysregulated expression of
microRNAs (miRNAs). However, the precise molecular mechanisms underlying this disorder …

Objective Synovial fibroblasts (SFs) with aberrant expression of microRNAs (miRNAs) are
critical pathogenic regulators in rheumatoid arthritis (RA), and studies analyzing the effect of …

ABSTRACT Preclinical Research Bone is a rigid and dynamic organ that undergoes
continuous turnover. Bone homeostasis is maintained by osteoclast‐mediated bone …

Glucocorticoid treatment reportedly increases the morbidity of osteoporotic or osteonecrotic
disorders. Exacerbated bone acquisition and escalated marrow adipogenesis are prominent …