Rho GTPases are key regulators of cytoskeletal dynamics and affect many cellular
processes, including cell polarity, migration, vesicle trafficking and cytokinesis. These …

Tumor heterogeneity results in differential response to therapy due to the existence of plastic
tumor cells, called cancer stem cells (CSCs), which exhibit the property of resistance to …

Lysophosphatidic acid receptors stimulate a Gα12/13/RhoA-dependent gene transcription
program involving the serum response factor (SRF) and its coactivator and oncogene …

Background There is increasing evidence in support of the role of lncRNAs in tumor cell
proliferation, differentiation and apoptosis. Methods We examined the expression of the …

The most frequent site of prostate cancer metastasis is the bone. Adhesion to bone-specific
factors may facilitate the selective metastasis of prostate cancer to the skeleton. Therefore …

The most frequent site of metastasis in human prostate cancer (PCa) is the bone.
Preferential adhesion of PCa cells to bone-specific factors may facilitate the selective …

Many studies have suggested a role for the members of the G 12 family of heterotrimeric G
proteins (Gα 12 and Gα 13) in oncogenesis and tumor cell growth. However, few studies …

Glioblastoma is the most aggressive and invasive brain tumor and has a poor prognosis;
elucidating the underlying molecular mechanisms is essential to select molecular targeted …

Prostate cancer (PCa) is initially regulated by androgens, such as testosterone and
dihydrotestosterone, which regulates cell proliferation and survival by activating the …

Acidic extracellular pH (pHe) is a common feature of the tumor microenvironment and has
been implicated in tumor invasion through the induction of protease secretion. Since …