Intrinsically disordered proteins and regions (collectively, IDRs) are pervasive across
proteomes in all kingdoms of life, help to shape biological functions and are involved in …

Embedding of cell-surface receptors into a membrane defines their dynamics but also
complicates experimental characterization of their signaling complexes. The hepatocyte …

Single-stranded RNA (ssRNA) plays a major role in the flow of genetic information–most
notably, in the form of messenger RNA (mRNA)–and in the regulation of biological …

Homotypic membrane fusion of the endoplasmic reticulum (ER) is mediated by dynamin-like
GTPase atlastin (ATL). This fundamental process relies on GTP-dependent domain …

The FET protein family, comprising FUS, EWS, and TAF15, plays crucial roles in mRNA
maturation, transcriptional regulation, and DNA damage response. Clinically, they are linked …

It has become increasingly evident that the conformational distributions of intrinsically
disordered proteins or regions are strongly dependent on their amino acid compositions and …

Proteins are dynamic systems whose structural preferences determine their function.
Unfortunately, building atomically detailed models of protein structure ensembles remains …

The assembly of membrane receptors into signaling complexes is at the origin of key cellular
events. Yet, we often lack detailed structural mechanistic understanding. Receptors are …

Proteins are investigated in increasingly more complex biological systems, where 19F NMR
is proving highly advantageous due to its high gyromagnetic ratio and background-free …

The human growth factor receptor MET is a receptor tyrosine kinase involved in cell
proliferation, migration, and survival. MET is also hijacked by the intracellular pathogen …