A Peptoid-like Approach Led to Lactam–Lactam Dimer Formation in 2-Hydroxy-N-alkyl-N-phenyl-nicotinamides and Their Polymorphism and Solvatomorphism

W Gao, Y Li, Y Zhoujin, Q Zeng, L Fang, S Parkin… - ACS …, 2023 - ACS Publications
Four 2-hydroxy-N-alkyl-N-phenyl-nicotinamides (1–4) were synthesized, and their crystal
structures were analyzed to investigate the effect of substitution on their crystal packing of N …

Polymorphism and cocrystal salt formation of 2-((2, 6-dichlorophenyl) amino) benzoic acid, harvest of a second form of 2-((2, 6-dimethylphenyl) amino) benzoic acid …

Y Zhoujin, Y Li, M Zhang, S Parkin, J Guo, T Li, F Yu… - …, 2022 - pubs.rsc.org
2-((2, 6-Dichlorophenyl) amino) benzoic acid (2-DCABA), a potential non-steroidal anti-
inflammatory drug and an analog of 2-((2, 6-dimethylphenyl) amino) benzoic acid (HDMPA) …

Double substitution leads to a highly polymorphic system in 5-methyl-2-m-tolylamino-benzoic acid

Y Zhoujin, Y Tao, P Zhou, S Parkin, T Li, J Guo, F Yu… - …, 2022 - pubs.rsc.org
Addition of methyl group (s) to either or both aromatic rings of fenamic acid (FA) afforded
three FA derivatives (1–3), designed to investigate the effect on the polymorphic behavior of …

Effect of homologation on the polymorphism of anthranilic acids

Y Zhoujin, Y Li, PY Liang, PP Zhou, S Parkin… - Crystal Growth & …, 2022 - ACS Publications
A series of homologues (1–4) of fenamic acid have been synthesized by varying the length
of the linker between the two aromatic rings, and their polymorphism has been investigated …

An investigation of the polymorphism of a potent nonsteroidal anti-inflammatory drug flunixin

H Liu, X Yang, S Wu, M Zhang, S Parkin, S Cao, T Li… - …, 2020 - pubs.rsc.org
Flunixin [2-(3-trifluoromethyl-2-methyl-phenylamino)-nicotinic acid, FLX], a potent
nonsteroidal anti-inflammatory drug widely used in veterinary medicine, was found to exist in …

Conformational flexibility and substitution pattern lead to polymorphism of 3-methyl-2-(phenylamino) benzoic acid

Y Tao, X Liu, Y Zhoujin, P Zhou, S Parkin, T Li, J Guo… - …, 2022 - pubs.rsc.org
To probe the effect of substitution on the benzoic acid ring on the polymorphism of
phenylaminobenzoic acids, five 3-methyl-2-(phenylamino) benzoic acids (MPABAs) were …

Orientation-dependent conformational polymorphs in two similar pyridine/pyrazine phenolic esters

A Samie, A Salimi - CrystEngComm, 2019 - pubs.rsc.org
On the basis of crystal engineering, two similar esters of phenyl pyridine-2-carboxylate (I)
and phenyl pyrazine-2-carboxylate (II) were designed and synthesized. The compounds …

anti/gauche Conformations Lead to Polymorphism in Homologous Phenylalkylamino-Nicotinic Acids

Y Zhoujin, Y Li, PY Liang, PP Zhou, S Parkin… - Crystal Growth & …, 2023 - ACS Publications
A series of phenylalkylamino-nicotinic acids (1–4) were synthesized by varying the length of
the linker between the pyridine and benzene rings, and their polymorphism was …

Effect of substituent size and isomerization on the polymorphism of 2-(naphthalenylamino)-benzoic acids

Y Liu, M Zhang, D Xu, S Parkin, T Li, C Li… - Crystal Growth & …, 2019 - ACS Publications
To probe the effect of substituent size and isomerization on the polymorphism of fenamic
acid (FA) derivatives, we synthesized two FA analogues, namely, 2-(naphthalen-1-ylamino) …

[HTML][HTML] N-(2, 6-Dichlorophenyl)-2-oxo-1, 2-dihydropyridine-3-carboxamide

N Tu, S Long - IUCrData, 2023 - scripts.iucr.org
Crystals of the title compound, C12H8Cl2N2O2, were obtained by slow evaporation of an
ethanolic solution. An intramolecular amideN—H⋯ O= Clactam hydrogen bond is observed …