Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

K Hynynen, RM Jones - Physics in Medicine & Biology, 2016 - iopscience.iop.org
Focused ultrasound offers a non-invasive way of depositing acoustic energy deep into the
body, which can be harnessed for a broad spectrum of therapeutic purposes, including …

MR‐guided focused ultrasound surgery, present and future

D Schlesinger, S Benedict, C Diederich… - Medical …, 2013 - Wiley Online Library
MR‐guided focused ultrasound surgery (MRgFUS) is a quickly developing technology with
potential applications across a spectrum of indications traditionally within the domain of …

Influence of the pressure field distribution in transcranial ultrasonic neurostimulation

Y Younan, T Deffieux, B Larrat, M Fink… - Medical …, 2013 - Wiley Online Library
Purpose: Low‐intensity focused ultrasound has been shown to stimulate the brain
noninvasively and without noticeable tissue damage. Such a noninvasive and localized …

Non-invasive transcranial ultrasound therapy based on a 3D CT scan: protocol validation and in vitro results

F Marquet, M Pernot, JF Aubry… - Physics in Medicine …, 2009 - iopscience.iop.org
A non-invasive protocol for transcranial brain tissue ablation with ultrasound is studied and
validated in vitro. The skull induces strong aberrations both in phase and in amplitude …

The road to clinical use of high-intensity focused ultrasound for liver cancer: technical and clinical consensus

JF Aubry, KB Pauly, C Moonen, G Haar, M Ries… - Journal of therapeutic …, 2013 - Springer
Clinical use of high-intensity focused ultrasound (HIFU) under ultrasound or MR guidance
as a non-invasive method for treating tumors is rapidly increasing. Tens of thousands of …

Aberration correction in abdominal histotripsy

E Yeats, TL Hall - International Journal of Hyperthermia, 2023 - Taylor & Francis
In transabdominal histotripsy, ultrasound pulses are focused into the body to noninvasively
destroy soft tissues via cavitation. However, the ability to focus is limited by phase …

High intensity focused ultrasound: past, present and future

G Ter Haar, C Coussios - International Journal of Hyperthermia, 2007 - Taylor & Francis
In a world in which diagnostic ultrasound is widely used and accepted, and is generally
thought to be ''safe'', it may be surprising to some that the initial medical interest in …

The impact of standing wave effects on transcranial focused ultrasound disruption of the blood–brain barrier in a rat model

MA O'Reilly, Y Huang, K Hynynen - Physics in Medicine & …, 2010 - iopscience.iop.org
Microbubble-mediated disruption of the blood–brain barrier (BBB) for targeted drug delivery
using focused ultrasound shows great potential as a therapy for a wide range of brain …

Ex vivo optimisation of a heterogeneous speed of sound model of the human skull for non-invasive transcranial focused ultrasound at 1 MHz

L Marsac, D Chauvet, R La Greca, AL Boch… - International Journal …, 2017 - Taylor & Francis
Transcranial brain therapy has recently emerged as a non-invasive strategy for the treatment
of various neurological diseases, such as essential tremor or neurogenic pain. However …

Focusing of high-intensity ultrasound through the rib cage using a therapeutic random phased array

S Bobkova, L Gavrilov, V Khokhlova, A Shaw… - Ultrasound in medicine & …, 2010 - Elsevier
A method for focusing high-intensity ultrasound (HIFU) through a rib cage that aims to
minimize heating of the ribs while maintaining high intensities at the focus (or foci) was …