Osteosarcoma is the most common primary malignant bone tumour in children and
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …

Survivors of childhood, adolescent, and young adult cancer, previously treated with
anthracycline chemotherapy (including mitoxantrone) or radiotherapy in which the heart was …

Survivors of childhood cancer treated with anthracycline chemotherapy or chest radiation
are at an increased risk of developing congestive heart failure. In this population, congestive …

1928 Circulation October 22, 2013 mental health, functional status, activity limitations,
cancerrelated pain, and cancer-related anxiety) declined moderately to severely in 44%. 5 …

Background Doxorubicin (DOX) is commonly used in the treatment of many types of cancers
but its cardiotoxicity is limiting its clinical use. Beyond its anticoagulant action, enoxaparin …

Background—The anthracycline doxorubicin is an effective chemotherapeutic agent used to
treat pediatric cancers but is associated with cardiotoxicity that can manifest many years …

In this article the difficulties that face survivors of childhood cancer therapy are presented,
and the late effects of such therapy, separated into nonmalignant and malignant late effects …

Methods This article is based on pertinent articles that were retrieved by a selective search
in PubMed and other databases, and on the guidelines of the European Society of …

Increasing numbers of children diagnosed with cancer will survive their primary malignancy.
Within this growing population of long-term survivors, considerable effort has been put forth …

Topoisomerase II is an enzyme essential for DNA replication, chromosome condensation
and chromosome segregation. Inhibitors of topoisomerase II are important drugs used in the …