Abstract 4D multi-image-based (4D MIB) optimization is a form of robust optimization where
different uncertainty scenarios, due to anatomy variations, are considered via multiple image …

Purpose To compare the dosimetric performances of small‐spot three‐dimensional (3D) and
four‐dimensional (4D) robustly optimized intensity‐modulated proton (IMPT) plans in the …

Objective. Proton arc therapy (PAT) is a new delivery technique that exploits the continuous
rotation of the gantry to distribute the therapeutic dose over many angular windows instead …

Compared to conventional radiotherapy using X-rays, proton therapy, in principle, allows
better conformity of the dose distribution to target volumes, at the cost of greater sensitivity to …

Purpose Intensity‐modulated proton therapy (IMPT) for lung tumors with a large tumor
movement is challenging due to loss of robustness in the target coverage. Often an upper …

Introduction. Treatment planning systems (TPS) are an essential component for simulating
and optimizing a radiation therapy treatment before administering it to the patient. It ensures …

Objective. The Dutch proton robustness evaluation protocol prescribes the dose of the
clinical target volume (CTV) to the voxel-wise minimum (VWmin) dose of 28 scenarios. This …

Background and purpose Intensity Modulated Proton Therapy (IMPT) faces challenges in
lung cancer treatment, like maintaining plan robustness for moving tumors against setup …

Background and purpose In the Netherlands, head-and-neck cancer (HNC) patients are
referred for proton therapy (PT) through model-based selection (MBS). However, treatment …

Intro. Current radiation therapy (RT) planning guidelines handle uncertainties in RT using
geometric margins. This approach is simple to use but oversimplifies complex underlying …