Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity

R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

Neuropeptidergic control of feeding: Focus on the galanin family of peptides

P Marcos, R Coveñas - International Journal of Molecular Sciences, 2021 - mdpi.com
Obesity/overweight are important health problems due to metabolic complications.
Dysregulation of peptides exerting orexigenic/anorexigenic effects must be investigated in …

Galanin is a potent modulator of cytokine and chemokine expression in human macrophages

A Koller, SM Brunner, R Bianchini, A Ramspacher… - Scientific reports, 2019 - nature.com
The regulatory peptide galanin is broadly distributed in the central-and peripheral nervous
systems as well as in non-neuronal tissues, where it exerts its diverse physiological …

Anti-obesity effect of intranasal administration of galanin-like peptide (GALP) in obese mice

H Kageyama, K Shiba, S Hirako, N Wada… - Scientific reports, 2016 - nature.com
Galanin-like peptide (GALP) has an anti-obesity effect in rats and mice. It has been reported
that the uptake of GALP by the brain is higher after intranasal administration than with …

The regulative effect of galanin family members on link of energy metabolism and reproduction

P Fang, B He, M Shi, G Kong, X Dong, Y Zhu, P Bo… - Peptides, 2015 - Elsevier
It is essential for the species survival that an efficient coordination between energy storage
and reproduction through endocrine regulation. The neuropeptide galanin, one of the …

The evolving roles of alarin in physiological and disease conditions, and its future potential clinical implications

EC Abebe, MA Mengstie, MA Seid, T Malik… - Frontiers in …, 2022 - frontiersin.org
Alarin is a member of the galanin family of neuropeptides that is widely expressed in the
central nervous system and peripheral tissues in humans and rodents. It was initially …

Insulin sensing by astrocytes is critical for normal thermogenesis and body temperature regulation

IH Manaserh, E Maly, M Jahromi… - Journal of …, 2020 - joe.bioscientifica.com
The important role of astrocytes in the central control of energy balance and glucose
homeostasis has recently been recognized. Changes in thermoregulation can lead to …

Autonomic nervous system-mediated effects of galanin-like peptide on lipid metabolism in liver and adipose tissue

S Hirako, N Wada, H Kageyama, F Takenoya… - Scientific reports, 2016 - nature.com
Galanin-like peptide (GALP) is a neuropeptide involved in the regulation of feeding behavior
and energy metabolism in mammals. While a weight loss effect of GALP has been reported …

Transcriptomic (DNA Microarray) and Metabolome (LC-TOF-MS) Analyses of the Liver in High-Fat Diet Mice after Intranasal Administration of GALP (Galanin-like …

F Takenoya, J Shibato, M Yamashita, A Kimura… - International Journal of …, 2023 - mdpi.com
The aim of this research was to test the efficacy and potential clinical application of
intranasal administration of galanin-like peptide (GALP) as an anti-obesity treatment under …

Acute central effects of alarin on the regulation on energy homeostasis

A Mikó, N Füredi, J Tenk, I Rostás, S Soós, M Solymár… - Neuropeptides, 2017 - Elsevier
Hypothalamic neuropeptides influence the main components of energy balance: metabolic
rate, food intake, body weight as well as body temperature, by exerting either an overall …