The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

The Janus kinases (JAKs) are a family of intracellular tyrosine kinases that play an essential
role in the signaling of numerous cytokines that have been implicated in the pathogenesis of …

Abstract Interleukin-1 receptor-associated kinases (IRAK1, IRAK2, IRAK3 [IRAK-M], and
IRAK4) are serine-threonine kinases involved in toll-like receptor and interleukin-1 signaling …

Introduction: The JAK kinases are a family of four tyrosine receptor kinases that play a
pivotal role in cytokine receptor signalling pathways via their interaction with signal …

Great successes have been achieved in developing small-molecule kinase inhibitors as
anticancer therapeutic agents. However, kinase deregulation plays essential roles not only …

Macrocycles are typically cyclic variants of inhibitors derived from uncyclized canonical
molecules or from natural products. For medicinal chemistry, drug-like macrocycles have …

Janus kinases (JAKs) are the non-receptor tyrosine kinases covering JAK1, JAK2, JAK3,
and TYK2 which regulate signal transductions of hematopoietic cytokines and growth factors …

In 2022, the US Food and Drug Administration approved a total of 16 marketing applications
for small molecule drugs, which not only provided dominant scaffolds but also introduced …

Colony stimulation factor-1 receptor (CSF-1R), which is also known as FMS kinase, plays an
important role in initiating inflammatory, cancer, and bone disorders when it is …

In this review, we describe the current knowledge of the biology of the JAKs. The JAK family
comprises the four nonreceptor tyrosine kinases JAK1, JAK2, JAK3, and Tyk2, all key …