CRISPR/Cas9 system exploits the concerted action of Cas9 nuclease and programmable
single guide RNA (sgRNA), and has been widely used for genome editing. The Cas9 …

In recent years there has been great progress with the implementation and utilization of
Clustered Regularly Interspaced Palindromic Repeats (CRISPR) and CRISPR-associated …

Brown and brown-like beige/brite adipocytes dissipate energy and have been proposed as
therapeutic targets to combat metabolic disorders. However, the therapeutic effects of cell …

Activation of energy expenditure in thermogenic fat is a promising strategy to improve
metabolic health, yet the dynamic processes that evoke this response are poorly …

Human thermogenic adipose tissue mitigates metabolic disease, thus raising much interest
in understanding its development and function. Here, we show that human thermogenic …

The failure of metabolic tissues to appropriately respond to insulin (“insulin resistance”) is an
early marker in the pathogenesis of type 2 diabetes. Protein phosphorylation is central to the …

Obesity is the major risk factor for metabolic diseases such as fatty liver, hyperlipidemia and
insulin resistance. Beige fat has been recognized as a therapeutic target considering its …

With rising global demand for food proteins and significant environmental impact associated
with conventional animal agriculture, it is important to develop sustainable alternatives to …

Obesity is a highly prevalent condition often associated with dysfunctional adipose tissue.
Stem cell-based therapies have become a promising tool for therapeutic intervention in the …

Adipose tissue (AT), once considered a mere fat storage organ, is now recognized as a
dynamic and complex entity crucial for regulating human physiology, including metabolic …