The interplay of oxidative stress and ROS scavenging: antioxidants as a therapeutic potential in sepsis

S Kumar, J Saxena, VK Srivastava, S Kaushik, H Singh… - Vaccines, 2022 - mdpi.com
Oxidative stress resulting from the disproportion of oxidants and antioxidants contributes to
both physiological and pathological conditions in sepsis. To combat this, the antioxidant …

Recent advances in machine learning-based models for prediction of antiviral peptides

F Ali, H Kumar, W Alghamdi, FA Kateb… - Archives of Computational …, 2023 - Springer
Viruses have killed and infected millions of people across the world. It causes several
chronic diseases like COVID-19, HIV, and hepatitis. To cope with such diseases and virus …

iAFPs-EnC-GA: identifying antifungal peptides using sequential and evolutionary descriptors based multi-information fusion and ensemble learning approach

A Ahmad, S Akbar, M Tahir, M Hayat, F Ali - Chemometrics and Intelligent …, 2022 - Elsevier
Fungal infections have become a serious health concern for human beings worldwide.
Fungal infections usually occur when the invading fungus appear on a particular part of the …

iAtbP-Hyb-EnC: Prediction of antitubercular peptides via heterogeneous feature representation and genetic algorithm based ensemble learning model

S Akbar, A Ahmad, M Hayat, AU Rehman… - Computers in Biology …, 2021 - Elsevier
Tuberculosis (TB) is a worldwide illness caused by the bacteria Mycobacterium tuberculosis.
Owing to the high prevalence of multidrug-resistant tuberculosis, numerous traditional …

StackedEnC-AOP: prediction of antioxidant proteins using transform evolutionary and sequential features based multi-scale vector with stacked ensemble learning

G Rukh, S Akbar, G Rehman, FK Alarfaj, Q Zou - BMC bioinformatics, 2024 - Springer
Background Antioxidant proteins are involved in several biological processes and can
protect DNA and cells from the damage of free radicals. These proteins regulate the body's …

XGB-DrugPred: computational prediction of druggable proteins using eXtreme gradient boosting and optimized features set

R Sikander, A Ghulam, F Ali - Scientific reports, 2022 - nature.com
Accurate identification of drug-targets in human body has great significance for designing
novel drugs. Compared with traditional experimental methods, prediction of drug-targets via …

AFP-CMBPred: Computational identification of antifreeze proteins by extending consensus sequences into multi-blocks evolutionary information

F Ali, S Akbar, A Ghulam, ZA Maher, A Unar… - Computers in Biology …, 2021 - Elsevier
In extremely cold environments, living organisms like plants, animals, fishes, and microbes
can die due to the intracellular ice formation in their bodies. To sustain life in such cold …

DBP-CNN: Deep learning-based prediction of DNA-binding proteins by coupling discrete cosine transform with two-dimensional convolutional neural network

O Barukab, F Ali, W Alghamdi, Y Bassam… - Expert Systems with …, 2022 - Elsevier
To improve the prediction of DNA-binding Proteins (DBPs), this paper presents a deep
learning-based method, named DBP-CNN. To efficiently extract the important features, we …

AIPs-DeepEnC-GA: predicting anti-inflammatory peptides using embedded evolutionary and sequential feature integration with genetic algorithm based deep …

A Raza, J Uddin, Q Zou, S Akbar, W Alghamdi… - … and Intelligent Laboratory …, 2024 - Elsevier
Inflammation is a biological response to harmful stimuli including infections, damaged cells,
tissue injuries, and toxic chemicals. It plays an essential role in facilitating tissue repair by …

AFP-SPTS: an accurate prediction of antifreeze proteins using sequential and pseudo-tri-slicing evolutionary features with an extremely randomized tree

A Khan, J Uddin, F Ali, H Kumar… - Journal of Chemical …, 2023 - ACS Publications
The development of intracellular ice in the bodies of cold-blooded living organisms may
cause them to die. These species yield antifreeze proteins (AFPs) to live in subzero …